2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| ALS Invest 1 B.V. | 10% Owner | 5,895,280 | Jul 8, 2022 |
| Morningside Venture Investments Ltd | 10% Owner | 4,997,302 | Aug 17, 2023 |
| Cohen Joshua B | CEO | 3,325,347 | Oct 2, 2025 |
| Klee Justin B. | CEO | 3,325,301 | Oct 2, 2025 |
| Viking Global Investors Lp | 10% Owner | 1,850,940 | Sep 9, 2022 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Mar 2, 2026 | Mar 4, 2026 | Klee Justin B. | CEO | Sell | 42.5 | -29,282 | -0.87% | ✗ | $423.8K |
| Mar 2, 2026 | Mar 4, 2026 | Cohen Joshua B | CEO | Sell | 42.5 | -29,282 | -0.87% | ✗ | $424.1K |
| Mar 2, 2026 | Mar 4, 2026 | Bedrosian Camille L | Chief Medical Officer | Sell | 42.5 | -6,461 | -3.68% | ✗ | $94.2K |
| Mar 2, 2026 | Mar 4, 2026 | FRATES JAMES M | CFO | Sell | 42.5 | -7,909 | -2.64% | ✗ | $114.9K |
| Mar 2, 2026 | Mar 4, 2026 | Mazzariello Gina | Chief Legal Officer | Sell | 42.5 | -6,844 | -4.84% | ✗ | $99.4K |
| Feb 23, 2026 | Feb 25, 2026 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -3,419 | -2.36% | ✗ | $48.4K |
| Feb 2, 2026 | Feb 4, 2026 | FRATES JAMES M | CFO | Sell | 42.5 | -3,557 | -1.17% | ✗ | $52.1K |
| Feb 2, 2026 | Feb 4, 2026 | Cohen Joshua B | CEO | Sell | 47.5 | -15,500 | -0.46% | ✗ | $227.6K |
| Feb 2, 2026 | Feb 4, 2026 | Mazzariello Gina | Chief Legal Officer | Sell | 42.5 | -3,448 | -2.33% | ✗ | $50.5K |
| Feb 2, 2026 | Feb 4, 2026 | Klee Justin B. | CEO | Sell | 47.5 | -15,500 | -0.46% | ✗ | $227.6K |
| Jan 15, 2026 | Jan 20, 2026 | Cohen Joshua B | CEO | Sell | 17.5 | -138,167 | -2.00% | ✗ | $1.9M |
| Jan 15, 2026 | Jan 20, 2026 | Klee Justin B. | CEO | Sell | 17.5 | -138,188 | -2.00% | ✗ | $1.9M |
| Jan 12, 2026 | Jan 14, 2026 | MILNE GEORGE M JR | Director | Neutral | 27.5 | -17,780 | -2.14% | ✗ | - |
| Jan 6, 2026 | Jan 8, 2026 | FRATES JAMES M | CFO | Sell | 46.3 | -3,326 | -1.08% | ✗ | $37K |
| Jan 6, 2026 | Jan 8, 2026 | Cohen Joshua B | CEO | Sell | 47.5 | -7,715 | -0.23% | ✗ | $85.6K |
| Jan 6, 2026 | Jan 8, 2026 | Klee Justin B. | CEO | Sell | 47.5 | -7,715 | -0.23% | ✗ | $85.6K |
| Dec 23, 2025 | Dec 23, 2025 | Firestone Karen | Director | Buy | 95.0 | +8,100 | 14.73% | ✗ | $100.8K |
| Dec 1, 2025 | Dec 3, 2025 | Bedrosian Camille L | Chief Medical Officer | Sell | 42.5 | -6,580 | -3.61% | ✗ | $94.4K |
| Sep 30, 2025 | Oct 2, 2025 | Klee Justin B. | CEO | Sell | 42.5 | -29,975 | -0.89% | ✗ | $431K |
| Sep 30, 2025 | Oct 2, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 42.5 | -8,828 | -5.62% | ✗ | $128.7K |
| Sep 30, 2025 | Oct 2, 2025 | FRATES JAMES M | CFO | Sell | 42.5 | -10,558 | -3.33% | ✗ | $154.7K |
| Sep 30, 2025 | Oct 2, 2025 | Cohen Joshua B | CEO | Sell | 42.5 | -29,933 | -0.89% | ✗ | $429.5K |
| Sep 30, 2025 | Oct 2, 2025 | Bedrosian Camille L | Chief Medical Officer | Sell | 42.5 | -12,039 | -6.19% | ✗ | $175.5K |
| Aug 12, 2025 | Aug 14, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 20.0 | -30,000 | -16.05% | ✓ | $246.1K |
| Jun 5, 2025 | Jun 9, 2025 | FONTEYNE PAUL R. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Firestone Karen | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Quimi Daphne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | MILNE GEORGE M JR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 9, 2025 | Zeiher Bernhardt G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 22, 2025 | May 27, 2025 | Mazzariello Gina | Chief Legal Officer | Neutral | 37.5 | -1,000 | -0.53% | ✗ | - |
| Mar 31, 2025 | Apr 2, 2025 | FRATES JAMES M | CFO | Sell | 46.3 | -10,896 | -3.32% | ✗ | $37.8K |
| Mar 31, 2025 | Apr 2, 2025 | Bedrosian Camille L | Chief Medical Officer | Sell | 46.3 | -12,425 | -6.01% | ✗ | $43.1K |
| Mar 31, 2025 | Apr 2, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -9,192 | -4.66% | ✗ | $32K |
| Mar 31, 2025 | Apr 2, 2025 | Cohen Joshua B | CEO | Sell | 45.0 | -21,490 | -0.64% | ✗ | $74.5K |
| Mar 31, 2025 | Apr 2, 2025 | Klee Justin B. | CEO | Sell | 45.0 | -21,490 | -0.64% | ✗ | $74.5K |
| Mar 20, 2025 | Mar 24, 2025 | Zeiher Bernhardt G | Director | Buy | 91.3 | +10,000 | 100.00% | ✗ | $37K |
| Mar 6, 2025 | Mar 10, 2025 | Mazzariello Gina | Chief Legal Officer | Neutral | 90.0 | +63,851 | 47.90% | ✗ | - |
| Mar 6, 2025 | Mar 10, 2025 | Bedrosian Camille L | Chief Medical Officer | Neutral | 90.0 | +68,420 | 49.44% | ✗ | - |
| Mar 6, 2025 | Mar 10, 2025 | Klee Justin B. | CEO | Neutral | 85.0 | +180,118 | 5.63% | ✗ | - |
| Mar 6, 2025 | Mar 10, 2025 | Cohen Joshua B | CEO | Neutral | 85.0 | +180,118 | 5.63% | ✗ | - |
| Mar 6, 2025 | Mar 10, 2025 | FRATES JAMES M | CFO | Neutral | 90.0 | +68,420 | 26.32% | ✗ | - |
| Mar 3, 2025 | Mar 5, 2025 | Klee Justin B. | CEO | Sell | 51.3 | -4,595 | -0.14% | ✗ | $14.5K |
| Mar 3, 2025 | Mar 5, 2025 | Cohen Joshua B | CEO | Sell | 51.3 | -4,595 | -0.14% | ✗ | $14.5K |
| Mar 3, 2025 | Mar 5, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 47.5 | -1,611 | -1.19% | ✗ | $5K |
| Feb 24, 2025 | Feb 26, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -4,169 | -3.00% | ✗ | $13.1K |
| Feb 5, 2025 | Feb 6, 2025 | Klee Justin B. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 3, 2025 | Feb 5, 2025 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -3,678 | -2.58% | ✗ | $12.8K |
| Feb 3, 2025 | Feb 5, 2025 | Cohen Joshua B | CEO | Sell | 51.3 | -11,851 | -0.37% | ✗ | $41.1K |
| Feb 3, 2025 | Feb 5, 2025 | Klee Justin B. | CEO | Sell | 51.3 | -11,855 | -0.37% | ✗ | $41.1K |
| Jan 24, 2025 | Jan 28, 2025 | MILNE GEORGE M JR | Director | Neutral | 27.5 | -27,910 | -3.25% | ✗ | - |
| Jan 6, 2025 | Jan 8, 2025 | Klee Justin B. | CEO | Sell | 51.3 | -7,471 | -0.23% | ✗ | $30.2K |
| Jan 6, 2025 | Jan 8, 2025 | Cohen Joshua B | CEO | Sell | 51.3 | -7,471 | -0.23% | ✗ | $30.2K |
| Dec 2, 2024 | Dec 3, 2024 | Bedrosian Camille L | Chief Medical Officer | Sell | 46.3 | -5,421 | -3.77% | ✗ | $30K |
| Nov 4, 2024 | Nov 6, 2024 | Klee Justin B. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 30, 2024 | Oct 2, 2024 | Klee Justin B. | CEO | Sell | 45.0 | -18,589 | -0.59% | ✗ | $59.4K |
| Sep 30, 2024 | Oct 2, 2024 | Cohen Joshua B | CEO | Sell | 45.0 | -18,589 | -0.57% | ✗ | $59.4K |
| Sep 30, 2024 | Oct 2, 2024 | Bedrosian Camille L | Chief Medical Officer | Sell | 46.3 | -11,442 | -7.37% | ✗ | $36.6K |
| Sep 30, 2024 | Oct 2, 2024 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -8,709 | -5.75% | ✗ | $27.8K |
| Sep 23, 2024 | Sep 25, 2024 | Cohen Joshua B | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 12, 2024 | Sep 16, 2024 | Cohen Joshua B | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 12, 2024 | Sep 16, 2024 | FRATES JAMES M | CFO | Buy | 95.0 | +40,000 | 18.18% | ✗ | $101.4K |
| Sep 5, 2024 | Sep 9, 2024 | Firestone Karen | Director | Buy | 95.0 | +50,000 | 1000.00% | ✗ | $106.6K |
| Aug 23, 2023 | Sep 5, 2024 | FRATES JAMES M | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 3, 2024 | Sep 5, 2024 | MILNE GEORGE M JR | Director | Buy | 95.0 | +100,000 | 13.18% | ✗ | $219.8K |
| Jun 6, 2024 | Jun 7, 2024 | FONTEYNE PAUL R. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Firestone Karen | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Zeiher Bernhardt G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | MILNE GEORGE M JR | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2024 | Jun 7, 2024 | Quimi Daphne | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 14, 2024 | May 16, 2024 | Quimi Daphne | Director | Buy | 90.0 | +5,000 | 100.00% | ✗ | $9.4K |
| May 15, 2024 | May 16, 2024 | Mazzariello Gina | Chief Legal Officer | Sell | 36.3 | -10,455 | -6.46% | ✓ | $19.7K |
| Apr 16, 2024 | Apr 18, 2024 | FRATES JAMES M | CFO | Neutral | 90.0 | +91,180 | 56.52% | ✗ | - |
| Apr 16, 2024 | Apr 18, 2024 | Cohen Joshua B | CEO | Neutral | 85.0 | +179,850 | 5.95% | ✗ | - |
| Apr 16, 2024 | Apr 18, 2024 | Mazzariello Gina | Chief Legal Officer | Neutral | 90.0 | +80,560 | 99.00% | ✗ | - |
| Apr 16, 2024 | Apr 18, 2024 | Klee Justin B. | CEO | Neutral | 85.0 | +179,850 | 6.08% | ✗ | - |
| Apr 16, 2024 | Apr 18, 2024 | Bedrosian Camille L | Chief Medical Officer | Neutral | 90.0 | +96,910 | 166.13% | ✗ | - |
| Mar 14, 2024 | Mar 15, 2024 | Zeiher Bernhardt G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 15, 2024 | Zeiher Bernhardt G | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 5, 2024 | Mar 7, 2024 | Cohen Joshua B | CEO | Sell | 47.5 | -4,135 | -0.14% | ✗ | $77.4K |
| Mar 5, 2024 | Mar 7, 2024 | Klee Justin B. | CEO | Sell | 47.5 | -4,135 | -0.14% | ✗ | $77.4K |
| Mar 5, 2024 | Mar 7, 2024 | FRATES JAMES M | CFO | Sell | 46.3 | -1,792 | -1.10% | ✗ | $33.6K |
| Mar 5, 2024 | Mar 7, 2024 | Mazzariello Gina | Chief Legal Officer | Sell | 46.3 | -1,540 | -1.86% | ✗ | $28.8K |
| Feb 26, 2024 | Feb 28, 2024 | FRATES JAMES M | CFO | Neutral | 90.0 | +40,000 | 32.49% | ✗ | - |
| Feb 26, 2024 | Feb 28, 2024 | Cohen Joshua B | CEO | Neutral | 82.5 | +126,667 | 4.37% | ✗ | - |
| Feb 26, 2024 | Feb 28, 2024 | Klee Justin B. | CEO | Neutral | 82.5 | +126,667 | 4.47% | ✗ | - |
| Feb 26, 2024 | Feb 28, 2024 | Mazzariello Gina | Chief Legal Officer | Neutral | 90.0 | +36,667 | 79.29% | ✗ | - |
| Feb 23, 2024 | Feb 27, 2024 | Mazzariello Gina | Chief Legal Officer | Sell | 42.5 | -2,838 | -5.78% | ✗ | $53.2K |
| Jan 25, 2024 | Jan 29, 2024 | MILNE GEORGE M JR | Director | Neutral | 27.5 | -9,100 | -1.19% | ✗ | - |
| Jan 16, 2024 | Jan 18, 2024 | MILNE GEORGE M JR | Director | Neutral | 27.5 | -94,350 | -10.95% | ✗ | - |
| Jan 9, 2024 | Jan 11, 2024 | Klee Justin B. | CEO | Sell | 47.5 | -5,841 | -0.21% | ✗ | $95.4K |
| Jan 9, 2024 | Jan 11, 2024 | FRATES JAMES M | CFO | Sell | 46.3 | -2,716 | -2.16% | ✗ | $44.3K |
| Jan 9, 2024 | Jan 11, 2024 | Cohen Joshua B | CEO | Sell | 47.5 | -5,841 | -0.20% | ✗ | $95.4K |
| Jan 9, 2024 | Jan 11, 2024 | Yeramian Patrick D | Chief Medical Officer | Sell | 46.3 | -2,812 | -1.35% | ✗ | $45.9K |
| Dec 27, 2023 | Dec 29, 2023 | Olinger Margaret | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2023 | Dec 19, 2023 | Firestone Karen | Director | Buy | 95.0 | +4,000 | 400.00% | ✗ | $59.9K |
| Nov 27, 2023 | Nov 29, 2023 | Bedrosian Camille L | Chief Medical Officer | Neutral | 90.0 | +58,333 | 100.00% | ✗ | - |
| Nov 29, 2023 | Bedrosian Camille L | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 16, 2023 | Nov 20, 2023 | Cohen Joshua B | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 31, 2023 | Nov 2, 2023 | FRATES JAMES M | CFO | Neutral | 85.0 | +11,072 | 9.65% | ✗ | - |
| Aug 23, 2023 | Aug 24, 2023 | FRATES JAMES M | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |