2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Baker Bros. Advisors Lp | 10% Owner | 7,211,484 | Sep 10, 2025 |
| Baker Bros. Advisors (GP) LLC | 10% Owner | 7,211,484 | Sep 10, 2025 |
| Baker Felix | 10% Owner | 7,211,484 | Sep 10, 2025 |
| Baker Julian | 10% Owner | 7,211,484 | Sep 10, 2025 |
| Laing Lance G. | — | 1,581,242 | Aug 22, 2024 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 11, 2026 | Feb 13, 2026 | ROMP CHARLES R | Director | Neutral | 90.0 | +215 | 100.00% | ✗ | - |
| Feb 13, 2026 | ROMP CHARLES R | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 27, 2026 | Jan 29, 2026 | Dalvey David | Director | Sell | 18.8 | -20,000 | -18.18% | ✓ | $2.4M |
| Dec 15, 2025 | Jan 9, 2026 | NIGON RICHARD | Director | Neutral | 27.5 | -19,975 | -18.32% | ✗ | - |
| Dec 5, 2025 | Dec 9, 2025 | Buller Richard E | Director | Sell | 20.0 | -3,000 | -27.81% | ✗ | $317.1K |
| Dec 4, 2025 | Dec 8, 2025 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 1, 2025 | Dec 3, 2025 | Buller Richard E | Director | Sell | 22.5 | -1,600 | -17.04% | ✗ | $107.9K |
| Nov 21, 2025 | Nov 24, 2025 | Dalvey David | Director | Sell | 20.0 | -15,000 | -12.00% | ✓ | $1.5M |
| Nov 19, 2025 | Nov 21, 2025 | Buller Richard E | Director | Sell | 20.0 | -4,400 | -22.06% | ✗ | $377.3K |
| Sep 11, 2025 | Sep 15, 2025 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 8, 2025 | Sep 10, 2025 | BAKER BROS. ADVISORS LP | 10% Owner | Buy | 88.8 | +170,100 | 1.09% | ✗ | $9.6M |
| Sep 2, 2025 | Sep 4, 2025 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 18, 2025 | Aug 20, 2025 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 18, 2025 | Aug 20, 2025 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 18, 2025 | Aug 20, 2025 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 1, 2025 | BAKER BROS. ADVISORS LP | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jul 28, 2025 | Jul 30, 2025 | Dalvey David | Director | Sell | 5.0 | -109,325 | -46.66% | ✓ | $4.8M |
| May 27, 2025 | May 29, 2025 | Buller Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2024 | May 29, 2025 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2025 | May 21, 2025 | Dalvey David | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2025 | May 21, 2025 | Buller Richard E | Director | Neutral | 90.0 | +1,029 | 13.26% | ✗ | - |
| May 19, 2025 | May 21, 2025 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2025 | May 21, 2025 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2025 | May 21, 2025 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 14, 2025 | Apr 15, 2025 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2025 | Mar 5, 2025 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2025 | Feb 18, 2025 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 6, 2025 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 2, 2024 | Dec 3, 2024 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 23, 2024 | Oct 25, 2024 | Buller Richard E | Director | Sell | 42.5 | -350 | -4.32% | ✓ | $5.7K |
| Aug 23, 2024 | Aug 27, 2024 | Buller Richard E | Director | Sell | 42.5 | -350 | -4.14% | ✓ | $5.9K |
| Aug 20, 2024 | Aug 26, 2024 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2024 | Aug 26, 2024 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2024 | Aug 22, 2024 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2024 | Aug 22, 2024 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2024 | Aug 22, 2024 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 21, 2024 | Jun 25, 2024 | Buller Richard E | Director | Sell | 42.5 | -350 | -3.97% | ✓ | $5.5K |
| Jun 10, 2024 | Jun 12, 2024 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | Dalvey David | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | Buller Richard E | Director | Neutral | 90.0 | +1,079 | 13.96% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 22, 2024 | May 24, 2024 | Buller Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 26, 2024 | Apr 30, 2024 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 24, 2024 | Apr 26, 2024 | Buller Richard E | Director | Sell | 42.5 | -350 | -4.33% | ✓ | $6K |
| Apr 8, 2024 | Apr 10, 2024 | Buller Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 18, 2024 | Mar 20, 2024 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 21, 2024 | Feb 23, 2024 | Buller Richard E | Director | Sell | 42.5 | -350 | -4.15% | ✓ | $5K |
| Feb 13, 2024 | Feb 15, 2024 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 13, 2024 | Feb 15, 2024 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 30, 2024 | Feb 1, 2024 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2024 | Jan 4, 2024 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 27, 2023 | Dec 28, 2023 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 20, 2023 | Dec 22, 2023 | Buller Richard E | Director | Sell | 42.5 | -350 | -3.99% | ✓ | $5K |
| Dec 14, 2023 | Dec 18, 2023 | Dalvey David | Director | Sell | 22.5 | -7,940 | -3.28% | ✗ | $116.6K |
| Dec 12, 2023 | Dec 14, 2023 | Dalvey David | Director | Sell | 22.5 | -7,060 | -2.83% | ✗ | $102.6K |
| Dec 7, 2023 | Dec 11, 2023 | Dalvey David | Director | Sell | 22.5 | -10,000 | -3.86% | ✗ | $149.3K |
| Nov 28, 2023 | Nov 30, 2023 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 25, 2023 | Oct 27, 2023 | Buller Richard E | Director | Sell | 42.5 | -350 | -3.83% | ✓ | $3.6K |
| Aug 30, 2023 | Sep 1, 2023 | Buller Richard E | Director | Sell | 42.5 | -350 | -3.69% | ✓ | $3.2K |
| Aug 25, 2023 | Aug 29, 2023 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 25, 2023 | Aug 29, 2023 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 25, 2023 | Aug 29, 2023 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 23, 2023 | Aug 25, 2023 | Buller Richard E | Director | Sell | 42.5 | -300 | -3.07% | ✓ | $2.9K |
| Jun 23, 2023 | Jun 27, 2023 | Buller Richard E | Director | Sell | 46.3 | -300 | -2.98% | ✓ | $3.5K |
| May 23, 2023 | May 25, 2023 | Buller Richard E | Director | Sell | 37.5 | -75 | -0.74% | ✗ | $832.5 |
| May 22, 2023 | May 24, 2023 | Furcht Leo | Director | Buy | 95.0 | +10,000 | 4000.00% | ✗ | $103.2K |
| May 19, 2023 | May 23, 2023 | Buller Richard E | Director | Sell | 27.5 | -350 | -3.33% | ✗ | $3.5K |
| May 15, 2023 | May 17, 2023 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2023 | May 17, 2023 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2023 | May 17, 2023 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2023 | May 17, 2023 | Dalvey David | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2023 | May 17, 2023 | Buller Richard E | Director | Neutral | 90.0 | +1,958 | 22.91% | ✗ | - |
| Apr 21, 2023 | Apr 25, 2023 | Buller Richard E | Director | Sell | 42.5 | -300 | -3.39% | ✓ | $2.9K |
| Feb 21, 2023 | Feb 23, 2023 | Buller Richard E | Director | Sell | 42.5 | -300 | -3.28% | ✓ | $3.4K |
| Feb 16, 2023 | Feb 21, 2023 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 16, 2023 | Feb 21, 2023 | Sullivan Brian F. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 16, 2023 | Feb 21, 2023 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 19, 2022 | Dec 21, 2022 | Buller Richard E | Director | Sell | 42.5 | -300 | -3.18% | ✓ | $3.3K |
| Dec 9, 2022 | Dec 13, 2022 | Sullivan Brian F. | CEO | Buy | 95.0 | +260,869 | 9.47% | ✗ | $1.5M |
| Nov 29, 2022 | Dec 6, 2022 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 22, 2022 | Nov 23, 2022 | Murphy Polly A. | Director | Buy | 91.3 | +5,000 | 100.00% | ✗ | $48.4K |
| Oct 20, 2022 | Oct 24, 2022 | Buller Richard E | Director | Sell | 42.5 | -300 | -3.08% | ✓ | $3K |
| Sep 14, 2022 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 12, 2022 | Sep 14, 2022 | Murphy Polly A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 9, 2022 | Sep 13, 2022 | NIGON RICHARD | Director | Buy | 83.8 | +5,000 | 4.49% | ✗ | $44.9K |
| Aug 30, 2022 | Sep 1, 2022 | Buller Richard E | Director | Sell | 27.5 | -100 | -1.02% | ✗ | $1K |
| Aug 25, 2022 | Aug 29, 2022 | Buller Richard E | Director | Sell | 27.5 | -350 | -3.43% | ✗ | $3.5K |
| Aug 19, 2022 | Aug 23, 2022 | Buller Richard E | Director | Sell | 46.3 | -300 | -2.86% | ✓ | $2.7K |
| Jun 24, 2022 | Jun 28, 2022 | Buller Richard E | Director | Sell | 46.3 | -300 | -2.78% | ✓ | $2.8K |
| May 25, 2022 | May 26, 2022 | NIGON RICHARD | Director | Buy | 67.5 | +754 | 0.68% | ✗ | $4.5K |
| May 23, 2022 | May 25, 2022 | Buller Richard E | Director | Sell | 27.5 | -750 | -6.49% | ✗ | $4.7K |
| May 19, 2022 | May 23, 2022 | Buller Richard E | Director | Sell | 27.5 | -250 | -2.12% | ✗ | $1.4K |
| May 17, 2022 | May 19, 2022 | NIGON RICHARD | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2022 | May 19, 2022 | Furcht Leo | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2022 | May 19, 2022 | Dalvey David | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2022 | May 19, 2022 | Buller Richard E | Director | Neutral | 90.0 | +3,273 | 38.39% | ✗ | - |
| May 17, 2022 | May 19, 2022 | Hahne Vicky | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2022 | May 19, 2022 | Laing Lance G. | Chief Science Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |