IONIS PHARMACEUTICALS INC (IONS)

Latest Insider Confidence Score

2026Q1

42.7
Bearish

Company insider confidence (by quarter)

2018Q1 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Ionis Pharmaceuticals Inc 10% Owner 98,322,397 Oct 14, 2020
Crooke Stanley T Chair 569,391 Jan 6, 2021
Monia Brett P CEO 179,572 Oct 8, 2025
Bennett C Frank EVP, Chief Scientific Officer 82,679 Sep 9, 2025
Wender Joseph H Director 80,035 Dec 3, 2025

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Mar 3, 2026 Mar 5, 2026 LOSCALZO JOSEPH Director Sell 46.3 -1,032 -1.40% ✓ $82.8K
Mar 3, 2026 Mar 5, 2026 KLEIN JOSEPH III Director Sell 8.8 -21,332 -65.75% ✓ $1.7M
Mar 3, 2026 Mar 5, 2026 Diaz Allene M. Director Sell 8.8 -54,878 -93.51% ✓ $4.4M
Mar 3, 2026 Mar 5, 2026 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 8.8 -20,106 -47.15% ✓ $1.6M
Mar 3, 2026 Mar 5, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Sell 8.1 -85,089 -51.37% ✓ $6.7M
Mar 3, 2026 Mar 5, 2026 Baroldi Joseph EVP, Chief Business Officer Sell 25.0 -6,659 -10.18% ✓ $531K
Feb 27, 2026 Mar 3, 2026 Swayze Eric EVP Research Buy 68.8 +256 0.79% ✗ $12.5K
Feb 27, 2026 Mar 3, 2026 O'NEIL PATRICK R. EVP CLO & General Counsel Buy 68.8 +376 0.52% ✗ $18.4K
Feb 27, 2026 Mar 3, 2026 Monia Brett P CEO Buy 56.3 +484 0.19% ✗ $23.7K
Feb 27, 2026 Mar 3, 2026 Birchler Brian EVP, Corp and Development Ops Buy 68.8 +351 0.53% ✗ $17.2K
Feb 27, 2026 Mar 3, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Buy 61.3 +261 0.26% ✗ $12.8K
Feb 2, 2026 Feb 13, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Feb 13, 2026 Feb 13, 2026 Swayze Eric EVP Research Sell 8.8 -15,642 -32.54% ✓ $1.3M
Feb 11, 2026 Feb 13, 2026 PARSHALL B LYNNE Director Sell 28.8 -5,000 -8.15% ✓ $413.6K
Feb 6, 2026 Feb 10, 2026 Monia Brett P CEO Sell 23.8 -29,430 -10.37% ✓ $2.5M
Feb 2, 2026 Feb 4, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Sell 16.3 -85,089 -26.10% ✗ $7.1M
Jan 29, 2026 Feb 2, 2026 Swayze Eric EVP Research Sell 97.5 +5,812 13.76% ✗ $512.4K
Jan 29, 2026 Feb 2, 2026 Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 92.5 +5,812 9.10% ✗ $515.6K
Jan 29, 2026 Feb 2, 2026 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 92.5 +5,812 8.78% ✗ $516.2K
Jan 29, 2026 Feb 2, 2026 Monia Brett P CEO Sell 100.0 +59,244 26.37% ✗ $5.2M
Jan 29, 2026 Feb 2, 2026 HOUGEN ELIZABETH L CFO Sell 92.5 +6,574 5.20% ✗ $581.7K
Jan 29, 2026 Feb 2, 2026 Birchler Brian EVP, Corp and Development Ops Sell 92.5 +5,812 9.62% ✗ $513K
Jan 29, 2026 Feb 2, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Sell 92.5 +5,536 5.84% ✗ $488.1K
Jan 29, 2026 Feb 2, 2026 Baroldi Joseph EVP, Chief Business Officer Sell 97.5 +4,982 11.02% ✗ $439.4K
Jan 22, 2026 Jan 23, 2026 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 25.0 -3,977 -15.00% ✓ $323.5K
Jan 15, 2026 Jan 20, 2026 YANG MICHAEL J. Director Neutral 52.5 - 0.00% ✗ -
Jan 15, 2026 Jan 20, 2026 Swayze Eric EVP Research Sell 40.0 -9,933 -19.03% ✗ $748.4K
Jan 15, 2026 Jan 20, 2026 Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 40.0 -9,302 -12.71% ✗ $703.1K
Jan 15, 2026 Jan 20, 2026 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 40.0 -9,191 -12.20% ✗ $697K
Jan 15, 2026 Jan 20, 2026 Monia Brett P CEO Sell 37.5 -44,034 -16.39% ✗ $3.3M
Jan 2, 2026 Jan 20, 2026 Kordasiewicz Holly B. EVP, Chief Development Officer Neutral 52.5 - 0.00% ✗ -
Jan 15, 2026 Jan 20, 2026 Kordasiewicz Holly B. EVP, Chief Development Officer Sell 40.0 -4,141 -21.96% ✗ $313.3K
Jan 15, 2026 Jan 20, 2026 Jenne Kyle EVP, Chf GL Pdt Str Ofcr Sell 42.5 -1,823 -10.01% ✗ $138.5K
Jan 15, 2026 Jan 20, 2026 HOUGEN ELIZABETH L CFO Sell 40.0 -12,922 -9.28% ✗ $972K
Jan 15, 2026 Jan 20, 2026 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 40.0 -8,353 -23.95% ✗ $634.4K
Jan 15, 2026 Jan 20, 2026 Birchler Brian EVP, Corp and Development Ops Sell 40.0 -8,480 -12.31% ✗ $636.9K
Jan 15, 2026 Jan 20, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Sell 40.0 -8,977 -8.65% ✗ $674.6K
Jan 15, 2026 Jan 20, 2026 Baroldi Joseph EVP, Chief Business Officer Sell 40.0 -8,056 -15.13% ✗ $610.3K
Jan 7, 2026 Jan 9, 2026 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 8.8 -44,199 -33.57% ✓ $3.8M
Jan 2, 2026 Jan 6, 2026 Jenne Kyle EVP, Chf GL Pdt Str Ofcr Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Swayze Eric EVP Research Sell 8.8 -23,463 -27.73% ✓ $1.9M
Jan 2, 2026 Jan 6, 2026 Schneider Eugene EVP, Chf Clinical Develop Ofcr Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 O'NEIL PATRICK R. EVP CLO & General Counsel Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Monia Brett P CEO Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Kordasiewicz Holly B. EVP, Chief Development Officer Neutral 52.5 - 0.00% ✗ -
Jan 6, 2026 Kordasiewicz Holly B. EVP, Chief Development Officer Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 HOUGEN ELIZABETH L CFO Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Devers Shannon L. EVP, Chief Human Resources Ofc Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Birchler Brian EVP, Corp and Development Ops Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 BENNETT C FRANK EVP, Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Jan 2, 2026 Jan 6, 2026 Baroldi Joseph EVP, Chief Business Officer Neutral 52.5 - 0.00% ✗ -
Dec 1, 2025 Dec 3, 2025 WENDER JOSEPH H Director Sell 5.0 -28,000 -34.98% ✓ $2.3M
Nov 25, 2025 Nov 28, 2025 KLEIN JOSEPH III Director Sell 7.5 -12,000 -42.19% ✓ $960K
Nov 25, 2025 Nov 28, 2025 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 5.0 -16,777 -48.95% ✓ $1.4M
Nov 18, 2025 Nov 20, 2025 WENDER JOSEPH H Director Neutral 52.5 - 0.00% ✗ -
Nov 19, 2025 Nov 20, 2025 HERMAN JOAN E Director Sell 17.5 -44,000 -32.31% ✗ $3.2M
Nov 6, 2025 Nov 7, 2025 Birchler Brian EVP, Corp and Development Ops Sell 22.5 -8,000 -14.08% ✓ $609.4K
Nov 5, 2025 Nov 7, 2025 Geary Richard S EVP, Chief Development Officer Sell 20.0 -34,639 -12.68% ✓ $2.6M
Nov 3, 2025 Nov 7, 2025 Geary Richard S EVP, Chief Development Officer Sell 22.5 -1,680 -1.39% ✗ $126.1K
Oct 30, 2025 Nov 3, 2025 WENDER JOSEPH H Director Sell 5.0 -28,000 -30.42% ✓ $2.1M
Oct 31, 2025 Nov 3, 2025 LOSCALZO JOSEPH Director Sell 5.0 -16,000 -30.58% ✓ $1.2M
Oct 31, 2025 Nov 3, 2025 Geary Richard S EVP, Chief Development Officer Sell 8.8 -90,929 -21.19% ✓ $6.8M
Oct 15, 2025 Oct 16, 2025 Swayze Eric EVP Research Sell 52.5 -53 -0.17% ✗ $3.9K
Oct 15, 2025 Oct 16, 2025 PARSHALL B LYNNE Director Sell 26.3 -5,000 -7.54% ✓ $358.7K
Oct 15, 2025 Oct 16, 2025 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 17.5 -7,263 -17.85% ✓ $530.6K
Oct 14, 2025 Oct 16, 2025 Birchler Brian EVP, Corp and Development Ops Sell 15.0 -23,900 -17.38% ✓ $1.7M
Oct 6, 2025 Oct 8, 2025 Swayze Eric EVP Research Sell 17.5 -6,849 -18.27% ✓ $472.7K
Oct 6, 2025 Oct 8, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 17.5 -13,441 -19.96% ✓ $937.3K
Oct 6, 2025 Oct 8, 2025 Monia Brett P CEO Sell 53.8 -437 -0.24% ✓ $30.3K
Oct 6, 2025 Oct 8, 2025 Baroldi Joseph EVP, Chief Business Officer Sell 37.5 -1,625 -4.64% ✓ $112.7K
Oct 1, 2025 Oct 2, 2025 WENDER JOSEPH H Director Sell 15.0 -16,800 -15.44% ✓ $1.1M
Oct 1, 2025 Oct 2, 2025 Swayze Eric EVP Research Sell 5.0 -27,114 -26.61% ✓ $1.8M
Oct 2, 2025 Oct 2, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 5.0 -64,664 -36.14% ✓ $4.4M
Oct 2, 2025 Oct 2, 2025 Baroldi Joseph EVP, Chief Business Officer Sell 5.0 -15,000 -30.00% ✓ $1M
Sep 29, 2025 Oct 1, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 15.0 -25,300 -18.13% ✓ $1.6M
Sep 30, 2025 Oct 1, 2025 Geary Richard S EVP, Chief Development Officer Sell 5.0 -57,900 -42.09% ✓ $3.8M
Sep 30, 2025 Oct 1, 2025 HOUGEN ELIZABETH L CFO Sell 5.0 -49,800 -31.07% ✓ $3.2M
Sep 12, 2025 Sep 16, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 41.3 -1,700 -2.89% ✓ $109.8K
Sep 9, 2025 Sep 11, 2025 Baroldi Joseph EVP, Chief Business Officer Sell 7.5 -11,950 -25.45% ✓ $742.8K
Sep 9, 2025 Sep 11, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 15.0 -21,000 -15.53% ✓ $1.4M
Sep 5, 2025 Sep 9, 2025 Baroldi Joseph EVP, Chief Business Officer Sell 51.3 -250 -0.71% ✓ $15.5K
Sep 5, 2025 Sep 9, 2025 BENNETT C FRANK EVP, Chief Scientific Officer Sell 30.0 -6,000 -6.77% ✓ $357.6K
Sep 2, 2025 Sep 4, 2025 Swayze Eric EVP Research Sell 12.5 -11,130 -22.89% ✓ $552.9K
Sep 2, 2025 Sep 4, 2025 WENDER JOSEPH H Director Sell 10.0 -28,000 -20.46% ✓ $1.6M
Sep 2, 2025 Sep 4, 2025 PARSHALL B LYNNE Director Sell 10.0 -20,000 -23.16% ✓ $1M
Sep 3, 2025 Sep 4, 2025 Monia Brett P CEO Sell 7.5 -203,814 -24.53% ✓ $12.3M
Sep 3, 2025 Sep 4, 2025 KLEIN JOSEPH III Director Sell 5.0 -28,000 -63.00% ✓ $1.7M
Sep 3, 2025 Sep 4, 2025 KLEIN JOSEPH III Director Sell 5.0 -28,000 -63.00% ✓ $1.7M
Sep 2, 2025 Sep 4, 2025 Geary Richard S EVP, Chief Development Officer Sell 22.5 -10,000 -11.15% ✓ $503.7K
Sep 3, 2025 Sep 4, 2025 Devers Shannon L. EVP, Chief Human Resources Ofc Sell 20.0 -3,162 -17.40% ✓ $192.9K
Sep 2, 2025 Sep 4, 2025 WENDER JOSEPH H Director Sell 10.0 -28,000 -20.46% ✓ $1.6M
Sep 3, 2025 Sep 4, 2025 Baroldi Joseph EVP, Chief Business Officer Sell 5.0 -32,800 -38.71% ✓ $1.9M
Sep 2, 2025 Sep 4, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Sell 3.8 -89,900 -56.18% ✓ $5.4M
Sep 2, 2025 Sep 4, 2025 BENNETT C FRANK EVP, Chief Scientific Officer Sell 15.0 -38,909 -16.98% ✓ $2.3M
Sep 3, 2025 Sep 4, 2025 LOSCALZO JOSEPH Director Sell 7.5 -16,000 -30.58% ✓ $962.4K
Sep 3, 2025 Sep 4, 2025 Schneider Eugene EVP, Chf Clinical Develop Ofcr Sell 5.0 -19,658 -27.62% ✓ $1.2M
Aug 29, 2025 Sep 3, 2025 O'NEIL PATRICK R. EVP CLO & General Counsel Buy 67.5 +331 0.58% ✗ $9.2K
Aug 29, 2025 Sep 3, 2025 Monia Brett P CEO Buy 55.0 +189 0.11% ✗ $5.2K
Aug 29, 2025 Sep 3, 2025 Geary Richard S EVP, Chief Development Officer Buy 55.0 +165 0.18% ✗ $4.6K
Aug 29, 2025 Sep 3, 2025 BENNETT C FRANK EVP, Chief Scientific Officer Buy 60.0 +213 0.23% ✗ $5.9K