2025Q4
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Ra Capital Management, L.P. | 10% Owner | 7,039,613 | May 26, 2022 |
| RA Capital Healthcare Fund LP | 10% Owner | 7,039,613 | May 26, 2022 |
| Kolchinsky Peter | 10% Owner | 7,039,613 | May 26, 2022 |
| Shah Rajeev M. | 10% Owner | 7,039,613 | May 26, 2022 |
| Grunberg Gregory | Director | 5,411,860 | Jun 21, 2021 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 9, 2026 | Purdy Brendan P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 9, 2026 | Posen Hillel D. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 9, 2026 | Minkowitz Avraham | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 9, 2026 | Colman Yonatan C. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 9, 2026 | Berger Chaim D. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 18, 2025 | Dec 22, 2025 | Lazar David E. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 3, 2025 | OXFORD FINANCE LLC | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 2, 2025 | Lazar David E. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 24, 2025 | Nov 26, 2025 | Lazar David E. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 26, 2025 | Lazar David E. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 23, 2025 | Oct 24, 2025 | Iwicki Mark T | Director | Sell | 22.5 | -154,894 | -59.94% | ✗ | $125.5K |
| Oct 22, 2025 | Oct 24, 2025 | Reumuth Mary | CFO | Sell | 26.3 | -33,197 | -53.45% | ✗ | $27.5K |
| Oct 22, 2025 | Oct 24, 2025 | Bazemore Todd | Director | Sell | 26.3 | -47,768 | -57.07% | ✗ | $39.6K |
| Oct 22, 2025 | Oct 24, 2025 | Brazzell Romulus K | Officer | Sell | 26.3 | -46,748 | -56.53% | ✗ | $38.8K |
| Oct 22, 2025 | Oct 24, 2025 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 26.3 | -20,806 | -33.25% | ✗ | $17.3K |
| Sep 30, 2025 | Oct 2, 2025 | BAKER BROS. ADVISORS LP | Other | Sell | 17.5 | -730,408 | -33.40% | ✗ | $1.1M |
| Aug 29, 2025 | Sep 2, 2025 | Bazemore Todd | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 24, 2025 | Jun 26, 2025 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 36.3 | -4,511 | -6.73% | ✓ | $18.1K |
| Jun 24, 2025 | Jun 26, 2025 | Reumuth Mary | CFO | Sell | 36.3 | -3,631 | -5.52% | ✓ | $14.6K |
| Jun 24, 2025 | Jun 26, 2025 | Bazemore Todd | Officer | Sell | 41.3 | -4,058 | -4.62% | ✓ | $16.3K |
| Jun 24, 2025 | Jun 26, 2025 | Brazzell Romulus K | Officer | Sell | 36.3 | -5,251 | -5.97% | ✓ | $21.1K |
| Jun 24, 2025 | Jun 26, 2025 | Iwicki Mark T | Director | Sell | 37.5 | -13,227 | -4.87% | ✓ | $53K |
| Jun 15, 2025 | Jun 17, 2025 | Rosen Howard B | Director | Neutral | 90.0 | +2,450 | 17.44% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Iwicki Mark T | Director | Neutral | 67.5 | +2,450 | 0.91% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Farid Marjan | Director | Neutral | 90.0 | +2,450 | 31.44% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | PERRY GREGORY D | Director | Neutral | 90.0 | +2,450 | 22.49% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | Myers C. Daniel | Director | Neutral | 90.0 | +2,450 | 30.92% | ✗ | - |
| Jun 15, 2025 | Jun 17, 2025 | KOVEN ANDREW I | Director | Neutral | 90.0 | +3,050 | 21.91% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Iwicki Mark T | Director | Sell | 41.3 | -10,866 | -3.88% | ✓ | $40.6K |
| Jun 3, 2025 | Jun 4, 2025 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 50.0 | -730 | -1.08% | ✓ | $2.7K |
| Jun 3, 2025 | Jun 4, 2025 | Reumuth Mary | CFO | Sell | 41.3 | -2,850 | -4.16% | ✓ | $10.7K |
| Jun 3, 2025 | Jun 4, 2025 | Bazemore Todd | Officer | Sell | 41.3 | -3,390 | -3.72% | ✓ | $12.7K |
| Jun 3, 2025 | Jun 4, 2025 | Brazzell Romulus K | Officer | Sell | 41.3 | -3,687 | -4.02% | ✓ | $13.8K |
| Jun 3, 2025 | Jun 4, 2025 | Iwicki Mark T | Director | Buy | 83.8 | +10,866 | 4.21% | ✓ | $40.6K |
| Mar 7, 2025 | Mar 10, 2025 | Bazemore Todd | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 10, 2025 | Brazzell Romulus K | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 6, 2025 | Jan 7, 2025 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 91.3 | +8,079 | 13.53% | ✓ | $15.4K |
| Jan 6, 2025 | Jan 7, 2025 | Bazemore Todd | Officer | Sell | 13.8 | -1,993 | -99.95% | ✓ | $15.2K |
| Jan 6, 2025 | Jan 7, 2025 | Brazzell Romulus K | Officer | Sell | 86.3 | +7,654 | 9.03% | ✓ | $18.7K |
| Jan 6, 2025 | Jan 7, 2025 | Iwicki Mark T | CEO | Sell | 86.3 | +16,321 | 6.19% | ✓ | $44.1K |
| Jan 6, 2025 | Jan 7, 2025 | Reumuth Mary | CFO | Sell | 91.3 | +8,394 | 13.95% | ✓ | $13K |
| Dec 30, 2024 | Dec 31, 2024 | BAKER BROS. ADVISORS LP | 10% Owner | Buy | 100.0 | +310,559 | 34.84% | ✗ | $2M |
| Jun 28, 2024 | BAKER BROS. ADVISORS LP | 10% Owner | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 26, 2024 | Jun 27, 2024 | Bazemore Todd | Officer | Sell | 36.3 | -4,653 | -5.31% | ✓ | $22.1K |
| Jun 26, 2024 | Jun 27, 2024 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 32.5 | -5,158 | -7.95% | ✓ | $24.5K |
| Jun 26, 2024 | Jun 27, 2024 | Reumuth Mary | CFO | Sell | 36.3 | -4,163 | -6.47% | ✓ | $19.8K |
| Jun 26, 2024 | Jun 27, 2024 | Iwicki Mark T | CEO | Sell | 32.5 | -15,168 | -5.44% | ✓ | $72K |
| Jun 26, 2024 | Jun 27, 2024 | Brazzell Romulus K | Officer | Sell | 36.3 | -5,489 | -6.13% | ✓ | $26.1K |
| Jun 11, 2024 | Jun 12, 2024 | Rosen Howard B | Director | Neutral | 90.0 | +1,400 | 11.07% | ✗ | - |
| Jun 11, 2024 | Jun 12, 2024 | Farid Marjan | Director | Neutral | 90.0 | +1,400 | 21.90% | ✗ | - |
| Jun 11, 2024 | Jun 12, 2024 | PERRY GREGORY D | Director | Neutral | 90.0 | +1,400 | 14.75% | ✗ | - |
| Jun 11, 2024 | Jun 12, 2024 | Myers C. Daniel | Director | Neutral | 90.0 | +1,400 | 21.46% | ✗ | - |
| Jun 11, 2024 | Jun 12, 2024 | KOVEN ANDREW I | Director | Neutral | 90.0 | +1,750 | 14.38% | ✗ | - |
| Jun 11, 2024 | Jun 12, 2024 | Blumenkranz Mark S. | Director | Neutral | 67.5 | +1,400 | 0.77% | ✗ | - |
| May 31, 2024 | Jun 3, 2024 | Bazemore Todd | Officer | Sell | 45.0 | -2,093 | -2.33% | ✓ | $12.7K |
| May 31, 2024 | Jun 3, 2024 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 53.8 | -231 | -0.35% | ✓ | $1.4K |
| May 31, 2024 | Jun 3, 2024 | Reumuth Mary | CFO | Sell | 45.0 | -1,786 | -2.70% | ✓ | $10.9K |
| May 31, 2024 | Jun 3, 2024 | Brazzell Romulus K | Officer | Sell | 45.0 | -2,002 | -2.19% | ✓ | $12.2K |
| May 31, 2024 | Jun 3, 2024 | Iwicki Mark T | CEO | Sell | 45.0 | -7,392 | -2.58% | ✓ | $45K |
| Jan 4, 2024 | Jan 5, 2024 | Trachtenberg Eric | Officer | Sell | 85.0 | +3,373 | 5.21% | ✓ | $8.3K |
| Jan 4, 2024 | Jan 5, 2024 | Kharabi Darius | CHIEF BUSINESS OFFICER | Sell | 85.0 | +3,215 | 5.19% | ✓ | $9.3K |
| Jan 4, 2024 | Jan 5, 2024 | Brazzell Romulus K | Officer | Sell | 86.3 | +4,883 | 5.64% | ✓ | $10.9K |
| Jan 4, 2024 | Jan 5, 2024 | Iwicki Mark T | CEO | Sell | 83.8 | +9,761 | 3.53% | ✓ | $30.5K |
| Jan 4, 2024 | Jan 5, 2024 | Reumuth Mary | CFO | Sell | 85.0 | +3,373 | 5.37% | ✓ | $8.3K |
| Jan 4, 2024 | Jan 5, 2024 | Bazemore Todd | Officer | Sell | 15.0 | -1,405 | -99.93% | ✓ | $9.5K |
| Jun 22, 2023 | Jun 23, 2023 | Farid Marjan | Director | Neutral | 90.0 | +4,792 | 299.50% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Myers C. Daniel | Director | Neutral | 90.0 | +4,884 | 297.80% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | KOVEN ANDREW I | Director | Neutral | 90.0 | +8,915 | 273.72% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Rosen Howard B | Director | Neutral | 90.0 | +9,088 | 254.99% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Kharabi Darius | CHIEF BUSINESS OFFICER | Neutral | 90.0 | +36,847 | 147.06% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | PERRY GREGORY D | Director | Neutral | 90.0 | +6,956 | 274.07% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Trachtenberg Eric | Officer | Neutral | 90.0 | +37,559 | 138.42% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Reumuth Mary | CFO | Neutral | 90.0 | +36,144 | 135.78% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Brazzell Romulus K | Officer | Neutral | 90.0 | +49,356 | 135.40% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Bazemore Todd | Officer | Neutral | 90.0 | +48,698 | 135.29% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Blumenkranz Mark S. | Director | Neutral | 82.5 | +4,884 | 2.77% | ✗ | - |
| Jun 22, 2023 | Jun 23, 2023 | Iwicki Mark T | CEO | Neutral | 90.0 | +158,873 | 135.00% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Rosen Howard B | Director | Neutral | 90.0 | +2,502 | 235.59% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Farid Marjan | Director | Neutral | 90.0 | +1,600 | 100.00% | ✗ | - |
| Feb 15, 2022 | Jun 2, 2023 | Kharabi Darius | CHIEF BUSINESS OFFICER | Neutral | 90.0 | +9,616 | 62.28% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | PERRY GREGORY D | Director | Neutral | 90.0 | +1,738 | 217.25% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Trachtenberg Eric | Officer | Neutral | 90.0 | +15,639 | 136.05% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Myers C. Daniel | Director | Neutral | 90.0 | +1,640 | 100.00% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Reumuth Mary | CFO | Neutral | 90.0 | +14,736 | 124.01% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | KOVEN ANDREW I | Director | Neutral | 90.0 | +2,197 | 207.26% | ✗ | - |
| Feb 15, 2023 | Jun 2, 2023 | Blumenkranz Mark S. | Director | Neutral | 90.0 | +69,711 | 33.13% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Brazzell Romulus K | Officer | Neutral | 90.0 | +17,916 | 96.66% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Bazemore Todd | Officer | Neutral | 90.0 | +21,158 | 142.61% | ✗ | - |
| May 31, 2023 | Jun 2, 2023 | Iwicki Mark T | CEO | Neutral | 90.0 | +71,715 | 156.02% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Kharabi Darius | CHIEF BUSINESS OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Trachtenberg Eric | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Reumuth Mary | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Brazzell Romulus K | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Bazemore Todd | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 14, 2023 | Mar 15, 2023 | Iwicki Mark T | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 4, 2023 | Jan 6, 2023 | Kharabi Darius | CHIEF BUSINESS OFFICER | Neutral | 90.0 | +9,525 | 161.06% | ✗ | - |
| Jan 4, 2023 | Jan 6, 2023 | Trachtenberg Eric | Officer | Sell | 90.0 | +9,465 | 466.26% | ✓ | $1.7K |
| Jan 4, 2023 | Jan 6, 2023 | Reumuth Mary | CFO | Sell | 90.0 | +9,465 | 391.44% | ✓ | $1.7K |
| Jan 4, 2023 | Jan 6, 2023 | Brazzell Romulus K | Officer | Sell | 90.0 | +12,727 | 219.09% | ✓ | $2.1K |
| Jan 4, 2023 | Jan 6, 2023 | Bazemore Todd | Officer | Sell | 90.0 | +12,738 | 607.15% | ✓ | $1.8K |