2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Baker Bros. Advisors Lp | Director | 32,600,975 | May 31, 2018 |
| 667, L.P. | Director | 32,600,975 | May 31, 2018 |
| Baker Bros. Advisors (GP) LLC | Director | 32,600,975 | May 31, 2018 |
| Baker Brothers Life Sciences LP | Director | 32,600,975 | May 31, 2018 |
| Baker Felix | Director | 32,600,975 | May 31, 2018 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Mar 2, 2026 | Mar 4, 2026 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 8.8 | -40,000 | -39.48% | ✓ | $1.8M |
| Feb 10, 2026 | Feb 12, 2026 | Quart Barry D | Director | Sell | 26.3 | -2,800 | -10.04% | ✓ | $126K |
| Feb 9, 2026 | Feb 11, 2026 | Ragosa Mark | CFO | Sell | 10.0 | -17,845 | -59.62% | ✓ | $772.3K |
| Feb 2, 2026 | Feb 4, 2026 | Quart Barry D | Director | Sell | 10.0 | -15,960 | -29.78% | ✓ | $721.6K |
| Feb 1, 2026 | Feb 4, 2026 | Levy Richard S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 8, 2026 | Jan 9, 2026 | Ragosa Mark | CFO | Sell | 10.0 | -12,000 | -38.60% | ✓ | $502.7K |
| Dec 15, 2025 | Dec 17, 2025 | Quart Barry D | Director | Sell | 7.5 | -20,129 | -61.60% | ✓ | $835.6K |
| Dec 15, 2025 | Dec 17, 2025 | Tessari Eben | COO | Sell | 7.5 | -12,048 | -41.96% | ✓ | $500.7K |
| Dec 8, 2025 | Dec 10, 2025 | Ragosa Mark | CFO | Sell | 5.0 | -42,841 | -57.95% | ✓ | $1.8M |
| Nov 26, 2025 | Dec 1, 2025 | Tessari Eben | COO | Sell | 52.5 | -200 | -0.87% | ✓ | $8.6K |
| Nov 17, 2025 | Nov 19, 2025 | Tessari Eben | COO | Sell | 7.5 | -12,470 | -35.44% | ✓ | $514.2K |
| Nov 12, 2025 | Nov 14, 2025 | Patel Sanj K | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 12, 2025 | Nov 14, 2025 | Ragosa Mark | CFO | Sell | 7.5 | -19,900 | -39.03% | ✓ | $814.7K |
| Oct 31, 2025 | Nov 4, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 5.0 | -82,542 | -57.37% | ✓ | $3.1M |
| Oct 28, 2025 | Oct 30, 2025 | Ragosa Mark | CFO | Sell | 53.8 | -100 | -0.32% | ✓ | $4.1K |
| Oct 20, 2025 | Oct 22, 2025 | Patel Sanj K | CEO | Sell | 2.5 | -257,969 | -30.81% | ✓ | $10M |
| Oct 20, 2025 | Oct 22, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 5.0 | -50,490 | -65.12% | ✓ | $2M |
| Oct 14, 2025 | Oct 16, 2025 | Tessari Eben | COO | Sell | 7.5 | -12,368 | -30.13% | ✓ | $465.8K |
| Oct 4, 2025 | Oct 8, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 45.0 | -85 | -0.22% | ✗ | $3.3K |
| Sep 29, 2025 | Oct 1, 2025 | Tessari Eben | COO | Sell | 5.0 | -42,000 | -54.86% | ✓ | $1.6M |
| Sep 15, 2025 | Sep 17, 2025 | Tessari Eben | COO | Sell | 7.5 | -16,400 | -32.19% | ✓ | $598K |
| Sep 4, 2025 | Sep 8, 2025 | Tessari Eben | COO | Sell | 5.0 | -98,660 | -52.60% | ✓ | $3.5M |
| Sep 4, 2025 | Sep 8, 2025 | Moat Ross | CHIEF CORP. & COMM. OFFICER | Sell | 10.0 | -3,523 | -27.23% | ✓ | $124.4K |
| Sep 1, 2025 | Sep 3, 2025 | Tessari Eben | COO | Sell | 22.5 | -19,063 | -12.59% | ✓ | $669.5K |
| Sep 1, 2025 | Sep 3, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 22.5 | -15,657 | -12.11% | ✓ | $539.5K |
| Sep 1, 2025 | Sep 3, 2025 | Moat Ross | CHIEF CORP. & COMM. OFFICER | Sell | 22.5 | -3,300 | -11.51% | ✗ | $110.9K |
| Sep 1, 2025 | Sep 3, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 22.5 | -3,676 | -2.93% | ✗ | $123.8K |
| Sep 1, 2025 | Sep 3, 2025 | Ragosa Mark | CFO | Sell | 22.5 | -3,820 | -5.87% | ✗ | $128.6K |
| Sep 1, 2025 | Sep 3, 2025 | Patel Sanj K | CEO | Sell | 20.0 | -14,160 | -4.11% | ✗ | $476.7K |
| Aug 18, 2025 | Aug 20, 2025 | Tessari Eben | COO | Sell | 7.5 | -16,200 | -28.72% | ✓ | $547.1K |
| Aug 12, 2025 | Aug 14, 2025 | Malley Thomas | Director | Sell | 16.3 | -177,769 | -61.86% | ✗ | $5.9M |
| Aug 6, 2025 | Aug 8, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 7.5 | -29,325 | -33.81% | ✓ | $954.5K |
| Jul 15, 2025 | Aug 7, 2025 | Tessari Eben | COO | Sell | 5.0 | -137,862 | -47.84% | ✓ | $4.6M |
| Aug 4, 2025 | Aug 6, 2025 | Ragosa Mark | CFO | Sell | 7.5 | -18,889 | -41.15% | ✓ | $621.3K |
| Jul 15, 2025 | Aug 6, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 17.5 | -16,505 | -19.98% | ✓ | $550K |
| Jul 30, 2025 | Aug 1, 2025 | Popovits Kimberly J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jul 14, 2025 | Jul 16, 2025 | Tessari Eben | COO | Sell | 7.5 | -18,900 | -27.77% | ✓ | $542.8K |
| Jul 1, 2025 | Jul 3, 2025 | Levy Richard S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 16, 2025 | Jun 18, 2025 | Tessari Eben | COO | Sell | 12.5 | -17,300 | -21.94% | ✓ | $489.2K |
| Jun 9, 2025 | Jun 11, 2025 | Quart Barry D | Director | Sell | 20.0 | -27,448 | -42.17% | ✗ | $833K |
| Jun 9, 2025 | Jun 11, 2025 | Tessari Eben | COO | Sell | 10.0 | -70,867 | -24.61% | ✓ | $2.2M |
| Jun 5, 2025 | Jun 5, 2025 | Cole G Bradley | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | BAKER BROS. ADVISORS LP | Director | Neutral | 67.5 | +16,794 | 0.58% | ✗ | - |
| Jun 5, 2025 | Jun 5, 2025 | Levy Richard S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 5, 2025 | Malley Thomas | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 5, 2025 | McCain Tracey L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 5, 2025 | Popovits Kimberly J | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 5, 2025 | Jun 5, 2025 | Quart Barry D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2025 | Jun 5, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 7.5 | -15,211 | -31.85% | ✓ | $437.3K |
| Jun 3, 2025 | Jun 5, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 7.5 | -27,594 | -74.56% | ✓ | $800.8K |
| Jun 3, 2025 | Jun 5, 2025 | Ragosa Mark | CFO | Sell | 7.5 | -18,299 | -40.39% | ✓ | $527K |
| May 23, 2025 | May 28, 2025 | Patel Sanj K | CEO | Sell | 15.0 | -86,270 | -17.75% | ✓ | $2.3M |
| May 20, 2025 | May 22, 2025 | Patel Sanj K | CEO | Sell | 45.0 | -2,349 | -1.12% | ✓ | $63.5K |
| May 19, 2025 | May 21, 2025 | Tessari Eben | COO | Sell | 22.5 | -12,000 | -14.22% | ✓ | $316.9K |
| May 13, 2025 | May 15, 2025 | Patel Sanj K | CEO | Sell | 45.0 | -2,872 | -1.37% | ✓ | $77.6K |
| May 7, 2025 | May 9, 2025 | Patel Sanj K | CEO | Sell | 45.0 | -8,095 | -1.98% | ✓ | $218.9K |
| May 7, 2025 | May 9, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 53.8 | -200 | -0.35% | ✓ | $5.4K |
| May 7, 2025 | May 9, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 7.5 | -17,647 | -35.16% | ✓ | $471K |
| May 2, 2025 | May 5, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 7.5 | -10,122 | -34.96% | ✓ | $283.4K |
| May 1, 2025 | May 5, 2025 | Tessari Eben | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 1, 2025 | May 5, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 1, 2025 | May 5, 2025 | Ragosa Mark | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 1, 2025 | May 5, 2025 | Patel Sanj K | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 1, 2025 | May 5, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 29, 2025 | May 1, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 5.0 | -87,269 | -82.25% | ✓ | $2.3M |
| Apr 29, 2025 | May 1, 2025 | Ragosa Mark | CFO | Sell | 5.0 | -88,395 | -52.17% | ✓ | $2.3M |
| Apr 26, 2025 | Apr 29, 2025 | Ragosa Mark | CFO | Sell | 26.3 | -479 | -1.74% | ✗ | $10.2K |
| Apr 21, 2025 | Apr 23, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 7.5 | -18,259 | -65.98% | ✓ | $370.5K |
| Apr 14, 2025 | Apr 16, 2025 | Tessari Eben | COO | Sell | 25.0 | -12,000 | -13.43% | ✓ | $245.8K |
| Apr 7, 2025 | Apr 9, 2025 | Tessari Eben | COO | Sell | 36.3 | -801 | -0.96% | ✗ | $16.2K |
| Apr 7, 2025 | Apr 9, 2025 | Ragosa Mark | CFO | Sell | 26.3 | -1,303 | -4.69% | ✗ | $26.4K |
| Apr 7, 2025 | Apr 9, 2025 | Patel Sanj K | CEO | Sell | 22.5 | -4,832 | -2.29% | ✗ | $98K |
| Apr 7, 2025 | Apr 9, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 26.3 | -734 | -1.26% | ✗ | $14.9K |
| Apr 7, 2025 | Apr 9, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 26.3 | -727 | -2.56% | ✗ | $14.7K |
| Apr 7, 2025 | Apr 9, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 26.3 | -1,666 | -4.87% | ✗ | $33.8K |
| Apr 1, 2025 | Apr 3, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 26.3 | -984 | -3.66% | ✗ | $21.4K |
| Apr 1, 2025 | Apr 3, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 26.3 | -991 | -1.75% | ✗ | $21.6K |
| Apr 1, 2025 | Apr 3, 2025 | Ragosa Mark | CFO | Sell | 26.3 | -1,617 | -6.05% | ✗ | $35.2K |
| Apr 1, 2025 | Apr 3, 2025 | Tessari Eben | COO | Sell | 26.3 | -1,034 | -1.27% | ✗ | $22.5K |
| Apr 1, 2025 | Apr 3, 2025 | Patel Sanj K | CEO | Sell | 22.5 | -5,321 | -2.58% | ✗ | $115.8K |
| Apr 1, 2025 | Apr 3, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 26.3 | -2,084 | -6.44% | ✗ | $45.4K |
| Mar 20, 2025 | Mar 24, 2025 | Ragosa Mark | CFO | Sell | 7.5 | -15,944 | -40.54% | ✓ | $368.5K |
| Mar 16, 2025 | Mar 19, 2025 | Ragosa Mark | CFO | Sell | 12.5 | -20,791 | -22.86% | ✓ | $480.1K |
| Jan 15, 2025 | Mar 19, 2025 | Moat Ross | CHIEF COMMERCIAL OFFICER | Sell | 77.5 | +826 | 1.81% | ✗ | $6.6K |
| Jan 15, 2025 | Mar 19, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 60.0 | +141 | 0.26% | ✗ | $7.4K |
| Mar 16, 2025 | Mar 19, 2025 | Tessari Eben | COO | Sell | 36.3 | -577 | -0.73% | ✗ | $13K |
| Mar 16, 2025 | Mar 19, 2025 | Patel Sanj K | CEO | Sell | 26.3 | -2,004 | -1.02% | ✗ | $45.3K |
| Mar 16, 2025 | Mar 19, 2025 | Paolini John F. | CHIEF MEDICAL OFFICER | Sell | 36.3 | -507 | -0.94% | ✗ | $11.5K |
| Mar 12, 2025 | Mar 14, 2025 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 10.0 | -9,051 | -25.44% | ✓ | $203.2K |
| Mar 12, 2025 | Mar 14, 2025 | Ragosa Mark | CFO | Sell | 7.5 | -36,372 | -61.30% | ✓ | $809.3K |
| Mar 10, 2025 | Mar 12, 2025 | Tessari Eben | COO | Sell | 22.5 | -12,409 | -13.95% | ✓ | $261.3K |
| Feb 10, 2025 | Feb 12, 2025 | Tessari Eben | COO | Sell | 22.5 | -14,000 | -14.59% | ✓ | $274K |
| Jan 13, 2025 | Jan 15, 2025 | Tessari Eben | COO | Sell | 22.5 | -14,000 | -13.60% | ✓ | $255.4K |
| Dec 16, 2024 | Dec 18, 2024 | Tessari Eben | COO | Sell | 17.5 | -23,017 | -19.34% | ✓ | $470.5K |
| Dec 6, 2024 | Dec 10, 2024 | Ragosa Mark | CFO | Sell | 7.5 | -27,829 | -37.74% | ✓ | $594K |
| Dec 3, 2024 | Dec 5, 2024 | Ragosa Mark | CFO | Sell | 17.5 | -15,116 | -18.00% | ✓ | $323K |
| Nov 27, 2024 | Dec 2, 2024 | Megna Michael R | CHIEF ACCOUNTING OFFICER | Sell | 25.0 | -8,646 | -14.01% | ✓ | $194.1K |
| Nov 18, 2024 | Nov 20, 2024 | Tessari Eben | COO | Sell | 22.5 | -17,000 | -14.17% | ✓ | $357.7K |
| Nov 7, 2024 | Nov 12, 2024 | Levy Richard S | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 6, 2024 | Nov 8, 2024 | Patel Sanj K | CEO | Sell | 5.0 | -89,561 | -32.11% | ✓ | $2.1M |