2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Redmile Group, LLC | — | 1,630,660 | Aug 25, 2020 |
| Green Jeremy | — | 1,630,660 | Aug 25, 2020 |
| Bvf Partners L P/Il | Director | 1,437,492 | Jul 1, 2025 |
| Biotechnology Value Fund L P | Director | 1,437,492 | Jul 1, 2025 |
| Bvf I Gp Llc | Director | 1,437,492 | Jul 1, 2025 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Mar 2, 2026 | Mar 4, 2026 | Adams Brian | Chief Legal Officer | Neutral | 85.0 | +4,125 | 7.86% | ✗ | - |
| Mar 2, 2026 | Mar 4, 2026 | Chadwick Jeremy G | COO | Sell | 92.5 | +6,617 | 9.85% | ✗ | $515.6K |
| Mar 2, 2026 | Mar 4, 2026 | Goodman Noah | Chief Business Officer | Neutral | 90.0 | +9,225 | 18.42% | ✗ | - |
| Mar 2, 2026 | Mar 4, 2026 | Gollob Jared | Chief Medical Officer | Sell | 92.5 | +7,142 | 6.49% | ✗ | $916.7K |
| Mar 2, 2026 | Mar 4, 2026 | Jacobs Bruce N. | CFO | Sell | 87.5 | +5,179 | 2.28% | ✗ | $1.1M |
| Mar 2, 2026 | Mar 4, 2026 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 2, 2026 | Mar 4, 2026 | Booth Bruce | Director | Sell | 43.1 | -81,866 | -1.76% | ✓ | $7.4M |
| Feb 25, 2026 | Feb 25, 2026 | Mainolfi Nello | CEO | Sell | 36.3 | -30,000 | -4.31% | ✓ | $2.7M |
| Feb 20, 2026 | Feb 20, 2026 | Esposito Pamela | Director | Sell | 11.3 | -2,500 | -100.00% | ✓ | $218.3K |
| Jan 20, 2026 | Jan 20, 2026 | Esposito Pamela | Director | Sell | 10.0 | -5,500 | -100.00% | ✓ | $373.5K |
| Jan 5, 2026 | Jan 6, 2026 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 31, 2025 | Dec 31, 2025 | Mainolfi Nello | CEO | Sell | 36.3 | -30,000 | -4.33% | ✓ | $2.3M |
| Dec 17, 2025 | Dec 17, 2025 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 17, 2025 | Dec 17, 2025 | Esposito Pamela | Director | Sell | 5.0 | -27,563 | -100.00% | ✓ | $2.3M |
| Dec 10, 2025 | Dec 12, 2025 | Booth Bruce | Director | Sell | 25.0 | -236,588 | -0.71% | ✗ | $21.7M |
| Dec 11, 2025 | Dec 11, 2025 | BAKER BROS. ADVISORS LP | Director | Buy | 100.0 | +2,005,813 | 30.16% | ✗ | $172.5M |
| Dec 8, 2025 | Dec 8, 2025 | Albers Jeffrey W. | Director | Sell | 7.5 | -5,000 | -100.00% | ✓ | $448.8K |
| Dec 8, 2025 | Dec 8, 2025 | Mainolfi Nello | CEO | Sell | 18.8 | -100,000 | -13.15% | ✓ | $8.9M |
| Dec 8, 2025 | Dec 8, 2025 | Gollob Jared | Chief Medical Officer | Sell | 5.0 | -49,307 | -30.95% | ✓ | $4.4M |
| Oct 29, 2025 | Oct 29, 2025 | Mainolfi Nello | CEO | Sell | 32.5 | -30,000 | -4.34% | ✓ | $1.8M |
| Oct 15, 2025 | Oct 15, 2025 | Gollob Jared | Chief Medical Officer | Sell | 5.0 | -59,576 | -35.13% | ✓ | $3.7M |
| Oct 13, 2025 | Oct 14, 2025 | Gollob Jared | Chief Medical Officer | Sell | 41.3 | -3,114 | -2.56% | ✓ | $186.8K |
| Oct 13, 2025 | Oct 14, 2025 | Albers Jeffrey W. | Director | Sell | 7.5 | -5,000 | -100.00% | ✓ | $295.9K |
| Sep 17, 2025 | Sep 17, 2025 | Jacobs Bruce N. | CFO | Sell | 5.0 | -79,220 | -25.84% | ✓ | $4M |
| Sep 16, 2025 | Sep 16, 2025 | Mainolfi Nello | CEO | Sell | 32.5 | -30,000 | -4.34% | ✓ | $1.5M |
| Sep 3, 2025 | Sep 3, 2025 | Adams Brian | Chief Legal Officer | Neutral | 90.0 | +52,500 | 100.00% | ✗ | - |
| Sep 3, 2025 | Adams Brian | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 30, 2025 | Jul 1, 2025 | BVF PARTNERS L P/IL | Director | Buy | 97.5 | +317,167 | 6.27% | ✗ | $14M |
| Jun 30, 2025 | Jun 30, 2025 | BAKER BROS. ADVISORS LP | Director | Buy | 100.0 | +655,500 | 10.93% | ✗ | $28.8M |
| Jun 25, 2025 | Jun 26, 2025 | BAKER BROS. ADVISORS LP | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Albers Jeffrey W. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Hrustanovic Gorjan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Esposito Pamela | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | MARAGANORE JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Booth Bruce | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Sandor Victor | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 26, 2025 | Ridloff Elena | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 11, 2025 | Jun 11, 2025 | Ridloff Elena | Director | Sell | 10.0 | -4,500 | -100.00% | ✓ | $225K |
| Jun 3, 2025 | Jun 3, 2025 | Esposito Pamela | Director | Sell | 10.0 | -5,000 | -100.00% | ✓ | $245.2K |
| Jun 3, 2025 | Jun 3, 2025 | Ridloff Elena | Director | Sell | 7.5 | -12,000 | -100.00% | ✓ | $553.2K |
| Jun 3, 2025 | Jun 3, 2025 | Mainolfi Nello | CEO | Sell | 32.5 | -30,000 | -4.34% | ✓ | $1.5M |
| Jun 3, 2025 | Jun 3, 2025 | Albers Jeffrey W. | Director | Sell | 7.5 | -6,349 | -100.00% | ✓ | $311.1K |
| May 23, 2025 | May 23, 2025 | Chadwick Jeremy G | COO | Sell | 42.5 | -2,575 | -3.73% | ✗ | $75.4K |
| Apr 8, 2025 | Apr 9, 2025 | Goodman Noah | Chief Business Officer | Neutral | 90.0 | +50,000 | 61396.40% | ✗ | - |
| Apr 9, 2025 | Goodman Noah | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 31, 2025 | Apr 1, 2025 | Jacobs Bruce N. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2025 | Mar 3, 2025 | Chiniara Ellen | Chief Legal Officer | Sell | 95.0 | +25,259 | 46.07% | ✗ | $68.2K |
| Mar 3, 2025 | Mar 3, 2025 | Chadwick Jeremy G | COO | Sell | 91.3 | +23,617 | 53.45% | ✗ | $42.1K |
| Mar 3, 2025 | Mar 3, 2025 | Jacobs Bruce N. | CFO | Sell | 95.0 | +22,965 | 12.84% | ✗ | $214.2K |
| Mar 3, 2025 | Mar 3, 2025 | Gollob Jared | Chief Medical Officer | Sell | 95.0 | +24,260 | 25.34% | ✗ | $174.8K |
| Mar 3, 2025 | Mar 3, 2025 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 10, 2025 | Jan 13, 2025 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 10, 2025 | Jan 13, 2025 | Jacobs Bruce N. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 6, 2025 | Jan 6, 2025 | Chiniara Ellen | Chief Legal Officer | Sell | 42.5 | -3,129 | -5.40% | ✗ | $130.6K |
| Dec 2, 2024 | Dec 2, 2024 | Esposito Pamela | Director | Sell | 10.0 | -2,500 | -100.00% | ✓ | $122.5K |
| Sep 17, 2024 | Sep 17, 2024 | Esposito Pamela | Director | Sell | 7.5 | -13,500 | -100.00% | ✓ | $651.8K |
| Aug 26, 2024 | Aug 26, 2024 | Albers Jeffrey W. | Director | Sell | 10.0 | -5,000 | -100.00% | ✓ | $245.5K |
| Aug 20, 2024 | Aug 22, 2024 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 20, 2024 | Aug 22, 2024 | BAKER BROS. ADVISORS LP | Director | Buy | 47.5 | +1 | 0.00% | ✗ | $46.4 |
| Jul 15, 2024 | Jul 16, 2024 | Gollob Jared | Chief Medical Officer | Sell | 20.0 | -39,600 | -11.77% | ✓ | $1.8M |
| Jul 9, 2024 | Jul 9, 2024 | Booth Bruce | Director | Sell | 37.5 | -453,960 | -1.73% | ✓ | $17.3M |
| Jul 1, 2024 | Jul 1, 2024 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 28, 2024 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 27, 2024 | Jun 28, 2024 | Jacobs Bruce N. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Esposito Pamela | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Booth Bruce | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Albers Jeffrey W. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Ridloff Elena | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Hrustanovic Gorjan | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | MARAGANORE JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Morgan Leigh | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Sandor Victor | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2024 | Jun 20, 2024 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Booth Bruce | Director | Sell | 47.5 | -26,940 | -0.17% | ✓ | $950.2K |
| Jun 7, 2024 | Jun 7, 2024 | Horobin Joanna | Director | Sell | 7.5 | -8,500 | -100.00% | ✓ | $280.4K |
| May 23, 2024 | May 23, 2024 | Chadwick Jeremy G | COO | Sell | 42.5 | -2,575 | -5.51% | ✗ | $90.1K |
| Mar 28, 2024 | Apr 1, 2024 | BAKER BROS. ADVISORS LP | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2024 | BAKER BROS. ADVISORS LP | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 14, 2024 | Mar 15, 2024 | Booth Bruce | Director | Sell | 42.5 | -127,543 | -0.39% | ✓ | $5.1M |
| Mar 11, 2024 | Mar 13, 2024 | Atlas Venture Fund X, L.P. | 10% Owner | Sell | 25.0 | -353,357 | -6.03% | ✓ | $14.9M |
| Mar 11, 2024 | Mar 13, 2024 | Booth Bruce | Director | Sell | 37.5 | -353,357 | -1.03% | ✓ | $14.9M |
| Mar 1, 2024 | Mar 4, 2024 | Gollob Jared | Chief Medical Officer | Sell | 95.0 | +21,031 | 28.15% | ✗ | $140K |
| Mar 1, 2024 | Mar 4, 2024 | Chadwick Jeremy G | COO | Neutral | 90.0 | +13,425 | 40.28% | ✗ | - |
| Mar 1, 2024 | Mar 4, 2024 | Chiniara Ellen | Chief Legal Officer | Neutral | 90.0 | +21,755 | 63.60% | ✗ | - |
| Mar 1, 2024 | Mar 4, 2024 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2024 | Mar 4, 2024 | Jacobs Bruce N. | CFO | Sell | 95.0 | +27,316 | 23.75% | ✗ | $164.7K |
| Feb 27, 2024 | Feb 29, 2024 | Gollob Jared | Chief Medical Officer | Sell | 51.3 | -400 | -0.53% | ✓ | $18K |
| Feb 20, 2024 | Feb 21, 2024 | Albers Jeffrey W. | Director | Sell | 10.0 | -5,000 | -100.00% | ✓ | $195.3K |
| Feb 9, 2024 | Feb 9, 2024 | Gollob Jared | Chief Medical Officer | Sell | 5.0 | -46,137 | -38.18% | ✓ | $1.6M |
| Jan 23, 2024 | Jan 23, 2024 | Albers Jeffrey W. | Director | Sell | 7.5 | -10,000 | -100.00% | ✓ | $300.5K |
| Jan 5, 2024 | Jan 9, 2024 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 4, 2024 | Jan 5, 2024 | Chiniara Ellen | Chief Legal Officer | Sell | 42.5 | -3,295 | -8.79% | ✗ | $74.4K |
| Jan 2, 2024 | Jan 2, 2024 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 2, 2023 | Nov 6, 2023 | BVF PARTNERS L P/IL | Director | Buy | 93.8 | +414,105 | 4.36% | ✗ | $5.3M |
| Nov 3, 2023 | Nov 6, 2023 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 8, 2023 | Aug 8, 2023 | Mainolfi Nello | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Sandor Victor | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Morgan Leigh | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | MARAGANORE JOHN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |