OnKure Therapeutics, Inc. (OKUR)

Latest Insider Confidence Score

2025Q4

49.1
Bearish

Company insider confidence (by quarter)

2021Q2 2025Q4

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Novo A/S 10% Owner 3,330,337 Jun 23, 2023
Baskett Forest 10% Owner 1,989,872 Apr 15, 2021
Sandell Scott D 10% Owner 1,989,872 Apr 15, 2021
Florence Anthony A. Jr. 10% Owner 1,989,872 Apr 15, 2021
Makhzoumi Mohamad 10% Owner 1,989,872 Apr 15, 2021

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Dec 31, 2025 Jan 2, 2026 Mathers Edward T Director Neutral 90.0 +3,911 34.31% ✗ -
Dec 31, 2025 Jan 2, 2026 Manke Isaac Director Neutral 90.0 +5,258 34.31% ✗ -
Dec 22, 2025 Dec 23, 2025 Saccomano Nicholas A CEO Sell 47.5 -87 -1.16% ✗ $258.2
Dec 22, 2025 Dec 23, 2025 Leverone Jason A. CFO Sell 47.5 -302 -1.82% ✗ $896.3
Sep 30, 2025 Oct 2, 2025 Mathers Edward T Director Neutral 90.0 +4,125 56.71% ✗ -
Sep 30, 2025 Oct 2, 2025 Manke Isaac Director Neutral 90.0 +5,545 56.70% ✗ -
Sep 22, 2025 Sep 24, 2025 Saccomano Nicholas A CEO Sell 47.5 -88 -2.45% ✗ $230.9
Sep 22, 2025 Sep 24, 2025 Leverone Jason A. CFO Sell 47.5 -303 -2.35% ✗ $794.9
Jun 30, 2025 Jul 2, 2025 Mathers Edward T Director Neutral 90.0 +4,694 181.94% ✗ -
Jun 30, 2025 Jul 2, 2025 Manke Isaac Director Neutral 90.0 +6,311 181.93% ✗ -
Jun 23, 2025 Jun 25, 2025 Saccomano Nicholas A CEO Sell 47.5 -88 -2.39% ✗ $209.8
Jun 23, 2025 Jun 25, 2025 Leverone Jason A. CFO Sell 47.5 -303 -2.29% ✗ $722.4
May 28, 2025 May 30, 2025 Mathers Edward T Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 30, 2025 Phillips Andrew John Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 30, 2025 Manke Isaac Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 30, 2025 Jansen Valerie Malyvanh Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 30, 2025 GREY MICHAEL G Director Neutral 52.5 - 0.00% ✗ -
May 28, 2025 May 30, 2025 Carruthers R Michael Director Neutral 52.5 - 0.00% ✗ -
May 27, 2025 ACORN BIOVENTURES 2, L.P. 10% Owner Neutral 52.5 - 0.00% ✗ -
May 15, 2025 May 19, 2025 Cormorant Asset Management, LP Other Sell 17.5 -1,813,439 -100.00% ✗ $3.4M
May 15, 2025 May 19, 2025 ACORN BIOVENTURES, L.P. 10% Owner Buy 100.0 +1,400,000 97.24% ✗ $2.6M
May 12, 2025 May 14, 2025 Cormorant Asset Management, LP 10% Owner Sell 26.3 -24,300 -1.32% ✗ $48.2K
Apr 4, 2025 Apr 8, 2025 Saccomano Nicholas A CEO Sell 47.5 -874 -19.18% ✗ $2.6K
Apr 4, 2025 Apr 8, 2025 Leverone Jason A. CFO Sell 47.5 -3,122 -19.12% ✗ $9.2K
Mar 31, 2025 Apr 2, 2025 Mathers Edward T Director Neutral 90.0 +2,580 100.00% ✗ -
Mar 31, 2025 Apr 2, 2025 Manke Isaac Director Neutral 90.0 +3,469 100.00% ✗ -
Jan 27, 2025 Jan 29, 2025 Saccomano Nicholas A CEO Neutral 52.5 - 0.00% ✗ -
Jan 27, 2025 Jan 29, 2025 Leverone Jason A. CFO Neutral 52.5 - 0.00% ✗ -
Jan 27, 2025 Jan 29, 2025 Hartley Dylan Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Jan 27, 2025 Jan 29, 2025 Agresta Samuel Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Oct 15, 2024 Cormorant Asset Management, LP 10% Owner Neutral 52.5 - 0.00% ✗ -
Oct 9, 2024 ACORN BIOVENTURES, L.P. 10% Owner Neutral 52.5 - 0.00% ✗ -
Oct 7, 2024 Oct 9, 2024 Leonard Braden Michael Other Neutral 90.0 +447,815 100.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Saccomano Nicholas A CEO Neutral 90.0 +4,556 100.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Phillips Andrew John Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Mathers Edward T Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Manke Isaac Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Leverone Jason A. CFO Neutral 90.0 +16,331 100.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Jansen Valerie Malyvanh Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Hartley Dylan Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 GREY MICHAEL G Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Carruthers R Michael Director Neutral 90.0 +4,939 100.00% ✗ -
Oct 4, 2024 Oct 8, 2024 Agresta Samuel Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Saccomano Nicholas A CEO Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Phillips Andrew John Director Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Manke Isaac Director Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Leverone Jason A. CFO Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Jansen Valerie Malyvanh Director Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Hartley Dylan Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Carruthers R Michael Director Neutral 52.5 - 0.00% ✗ -
Oct 8, 2024 Agresta Samuel Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Sep 24, 2024 Sep 26, 2024 Leonard Braden Michael 10% Owner Buy 82.5 +98,346 2.25% ✗ $144.7K
Sep 17, 2024 Sep 19, 2024 Leonard Braden Michael 10% Owner Buy 82.5 +56,106 1.30% ✗ $76.2K
Sep 12, 2024 Sep 16, 2024 Leonard Braden Michael 10% Owner Buy 92.5 +358,923 9.05% ✗ $484.3K
Aug 13, 2024 Aug 14, 2024 Leonard Braden Michael 10% Owner Buy 92.5 +271,826 7.36% ✗ $380.6K
May 14, 2024 May 16, 2024 Leonard Braden Michael 10% Owner Buy 97.5 +414,281 12.64% ✗ $639.6K
May 16, 2024 Leonard Braden Michael 10% Owner Neutral 52.5 - 0.00% ✗ -
Aug 28, 2023 Aug 29, 2023 Hall Ashley Chief Development Officer Sell 22.5 -15,625 -28.29% ✗ $98.1K
Jul 26, 2023 Jul 27, 2023 GREY MICHAEL G Chair Neutral 27.5 -50,000 -7.37% ✗ -
Jun 23, 2023 Jun 23, 2023 Novo Holdings A/S 10% Owner Sell 20.0 -100,000 -2.92% ✗ $709.7K
Jun 6, 2023 Jun 8, 2023 Mathers Edward T Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 Blunt Roshawn A. Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 Hoelscher Paul W. Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 O'Donnell Niall Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 Seltzer Stacey Denenberg Director Neutral 52.5 - 0.00% ✗ -
Jun 6, 2023 Jun 8, 2023 Dube Eric M Director Neutral 52.5 - 0.00% ✗ -
May 8, 2023 May 10, 2023 O'Donnell Niall Director Buy 95.0 +125,000 6.06% ✗ $1M
Dec 9, 2022 Dec 13, 2022 Lam Jennifer VP of Finance & Administration Neutral 52.5 - 0.00% ✗ -
Dec 9, 2022 Dec 13, 2022 Hall Ashley Chief Development Officer Neutral 52.5 - 0.00% ✗ -
Dec 9, 2022 Dec 13, 2022 FLESHER GREGORY J. CEO Neutral 52.5 - 0.00% ✗ -
Aug 12, 2022 Dec 13, 2022 Dorenbaum Alejandro Chief Medical Officer Neutral 27.5 -22,348 -42.69% ✗ -
Dec 9, 2022 Dec 13, 2022 Cruse Michael COO Neutral 52.5 - 0.00% ✗ -
Sep 1, 2022 Sep 2, 2022 Cruse Michael COO Buy 91.3 +7,500 19.76% ✗ $25.4K
Aug 31, 2022 Sep 2, 2022 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Aug 29, 2022 Aug 31, 2022 Cruse Michael COO Buy 91.3 +7,255 23.63% ✗ $23.2K
Aug 2, 2022 Aug 2, 2022 Blunt Roshawn A. Director Neutral 52.5 - 0.00% ✗ -
Aug 2, 2022 Blunt Roshawn A. Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 Mathers Edward T Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 GREY MICHAEL G Chair Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 Hoelscher Paul W. Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 Dube Eric M Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 Muralidhar Bali Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 Seltzer Stacey Denenberg Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 3, 2022 O'Donnell Niall Director Neutral 52.5 - 0.00% ✗ -
Apr 5, 2022 Lam Jennifer VP of Finance & Administration Neutral 52.5 - 0.00% ✗ -
Mar 2, 2022 Mar 4, 2022 Cruse Michael COO Neutral 52.5 - 0.00% ✗ -
Jan 20, 2022 Jan 24, 2022 Hoelscher Paul W. Director Neutral 52.5 - 0.00% ✗ -
Jan 24, 2022 Hoelscher Paul W. Director Neutral 52.5 - 0.00% ✗ -
Dec 10, 2021 Dec 14, 2021 Jindal Vineet R. CFO Neutral 90.0 +30,000 454.55% ✗ -
Dec 10, 2021 Dec 14, 2021 FLESHER GREGORY J. CEO Neutral 90.0 +100,000 1041.67% ✗ -
Dec 10, 2021 Dec 14, 2021 Dorenbaum Alejandro Chief Medical Officer Neutral 90.0 +30,000 134.24% ✗ -
Dec 10, 2021 Dec 14, 2021 Cruse Michael Senior VP-Corporate Operations Neutral 90.0 +25,000 609.76% ✗ -
Nov 12, 2021 Nov 15, 2021 Hall Ashley Chief Development Officer Neutral 90.0 +30,000 100.00% ✗ -
Oct 14, 2021 Hall Ashley Chief Development Officer Neutral 52.5 - 0.00% ✗ -
Aug 25, 2021 Aug 26, 2021 Jindal Vineet R. CFO Buy 91.3 +5,000 100.00% ✗ $37.2K
Aug 25, 2021 Aug 26, 2021 FLESHER GREGORY J. CEO Buy 95.0 +8,000 100.00% ✗ $64K
Aug 25, 2021 Aug 26, 2021 Cruse Michael Senior VP-Corporate Operations Buy 91.3 +2,500 100.00% ✗ $18.6K
Jul 14, 2021 Jul 15, 2021 Muralidhar Bali Director Buy 92.5 +111,736 5.69% ✗ $949.8K