Prelude Therapeutics Inc (PRLD)

Latest Insider Confidence Score

2026Q1

50.0
Bullish

Company insider confidence (by quarter)

2020Q3 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Orbimed Advisors Llc Director 526,300 May 24, 2023
OrbiMed Capital GP VI LLC Director 526,300 May 24, 2023
Orbimed Capital Llc Director 526,300 May 24, 2023
Combs Andrew Chief Chemistry Officer 480,123 Mar 27, 2025
Vaddi Krishna CEO 425,000 Mar 4, 2024

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Feb 4, 2026 Feb 5, 2026 Combs Andrew Chief Chemistry Officer Neutral 52.5 - 0.00% ✗ -
Feb 4, 2026 Feb 5, 2026 Scherle Peggy Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Feb 4, 2026 Feb 5, 2026 Lim Bryant David CFO Neutral 52.5 - 0.00% ✗ -
Feb 4, 2026 Feb 5, 2026 Vaddi Krishna CEO Neutral 52.5 - 0.00% ✗ -
Nov 5, 2025 Nov 7, 2025 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Oct 17, 2025 Oct 20, 2025 Dorton Katina Director Neutral 52.5 - 0.00% ✗ -
Oct 20, 2025 Dorton Katina Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2025 Oct 7, 2025 Huang Jane President Sell 47.5 -3,355 -3.72% ✗ $4.9K
Jul 4, 2025 Jul 8, 2025 Huang Jane President Sell 47.5 -3,355 -3.98% ✗ $2.7K
Jun 12, 2025 Jun 13, 2025 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Jun 13, 2025 Scherer Paul C Director Neutral 52.5 - 0.00% ✗ -
Jun 12, 2025 Jun 13, 2025 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Jun 12, 2025 Jun 13, 2025 Dier Mardi Director Neutral 52.5 - 0.00% ✗ -
Jun 12, 2025 Jun 13, 2025 FRIEDMAN PAUL A Director Neutral 52.5 - 0.00% ✗ -
Jun 12, 2025 Jun 13, 2025 Bonita David P Director Neutral 52.5 - 0.00% ✗ -
Jun 12, 2025 Jun 13, 2025 Babler Martin Director Neutral 52.5 - 0.00% ✗ -
Apr 4, 2025 Apr 7, 2025 Huang Jane President Sell 47.5 -3,355 -4.29% ✗ $2.3K
Mar 25, 2025 Mar 27, 2025 Combs Andrew Chief Chemistry Officer Buy 95.0 +100,000 26.31% ✗ $69.3K
Mar 25, 2025 Mar 27, 2025 Vaddi Krishna CEO Buy 97.5 +675,000 22.54% ✗ $467.4K
Mar 20, 2025 Mar 24, 2025 Vaddi Krishna CEO Buy 68.8 +20,416 0.69% ✗ $14.9K
Mar 14, 2025 Mar 18, 2025 Vaddi Krishna CEO Buy 78.8 +39,105 1.33% ✗ $29.5K
Mar 12, 2025 Mar 14, 2025 Vaddi Krishna CEO Buy 87.5 +97,500 3.44% ✗ $69.6K
Feb 4, 2025 Feb 5, 2025 Lim Bryant David CFO Neutral 52.5 - 0.00% ✗ -
Feb 4, 2025 Feb 5, 2025 Scherle Peggy Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Feb 4, 2025 Feb 5, 2025 Combs Andrew Chief Chemistry Officer Neutral 52.5 - 0.00% ✗ -
Feb 4, 2025 Feb 5, 2025 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Feb 4, 2025 Feb 5, 2025 Vaddi Krishna CEO Neutral 52.5 - 0.00% ✗ -
Jan 4, 2025 Jan 7, 2025 Huang Jane President Sell 47.5 -3,859 -5.31% ✗ $5.4K
Dec 31, 2024 Jan 3, 2025 Vaddi Krishna CEO Buy 55.0 +5,000 0.18% ✗ $6K
Dec 30, 2024 Jan 2, 2025 Vaddi Krishna CEO Buy 61.3 +10,000 0.35% ✗ $12K
Dec 20, 2024 Dec 26, 2024 Combs Andrew Chief Chemistry Officer Buy 95.0 +63,075 20.05% ✗ $85.5K
Dec 19, 2024 Dec 20, 2024 Lim Bryant David CFO Buy 91.3 +25,000 1041.67% ✗ $22.6K
Dec 18, 2024 Dec 20, 2024 Vaddi Krishna CEO Buy 87.5 +106,888 3.94% ✗ $99.3K
Oct 4, 2024 Oct 7, 2024 Huang Jane President Sell 47.5 -3,349 -5.02% ✗ $6.7K
Jul 4, 2024 Jul 8, 2024 Huang Jane President Sell 46.3 -3,347 -5.52% ✗ $12K
Jun 14, 2024 Jun 18, 2024 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Jun 14, 2024 Jun 18, 2024 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Jun 14, 2024 Jun 18, 2024 FRIEDMAN PAUL A Director Neutral 52.5 - 0.00% ✗ -
Jun 14, 2024 Jun 18, 2024 Dier Mardi Director Neutral 52.5 - 0.00% ✗ -
Jun 14, 2024 Jun 18, 2024 Bonita David P Director Neutral 52.5 - 0.00% ✗ -
Jun 14, 2024 Jun 18, 2024 Babler Martin Director Neutral 52.5 - 0.00% ✗ -
May 14, 2024 May 16, 2024 Lim Bryant David CFO Neutral 52.5 - 0.00% ✗ -
Apr 4, 2024 Apr 8, 2024 Huang Jane President Sell 46.3 -3,347 -6.13% ✗ $15.9K
Mar 1, 2024 Mar 4, 2024 Lim Bryant David Chief Legal Officer, Corp Sec. Neutral 52.5 - 0.00% ✗ -
Mar 1, 2024 Mar 4, 2024 Scherle Peggy Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Mar 1, 2024 Mar 4, 2024 Combs Andrew Chief Chemistry Officer Neutral 52.5 - 0.00% ✗ -
Mar 1, 2024 Mar 4, 2024 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -
Mar 1, 2024 Mar 4, 2024 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Mar 1, 2024 Mar 4, 2024 Vaddi Krishna CEO Neutral 52.5 - 0.00% ✗ -
Jan 4, 2024 Jan 8, 2024 Huang Jane President Sell 46.3 -3,844 -7.83% ✗ $14.5K
Dec 13, 2023 Dec 13, 2023 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Oct 4, 2023 Oct 6, 2023 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Jul 4, 2023 Jul 6, 2023 Huang Jane President Sell 46.3 -3,242 -9.65% ✗ $15.1K
Jun 16, 2023 Jun 21, 2023 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 FRIEDMAN PAUL A Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 Dier Mardi Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 Bonita David P Director Neutral 52.5 - 0.00% ✗ -
Jun 16, 2023 Jun 21, 2023 Babler Martin Director Neutral 52.5 - 0.00% ✗ -
May 24, 2023 May 26, 2023 Vaddi Krishna CEO Buy 55.0 +1,900 0.07% ✗ $9.8K
May 24, 2023 May 25, 2023 Lim Bryant David Chief Legal Officer, Corp Sec. Buy 91.3 +2,400 100.00% ✗ $12.9K
May 23, 2023 May 25, 2023 Chardonnet Laurent CFO Buy 91.3 +5,000 13.45% ✗ $27.5K
May 23, 2023 May 25, 2023 Vaddi Krishna CEO Buy 65.0 +11,856 0.44% ✗ $66.7K
May 22, 2023 May 24, 2023 ORBIMED ADVISORS LLC Director Buy 95.0 +869,565 9.40% ✗ $5M
May 22, 2023 May 24, 2023 Bonita David P Director Buy 95.0 +869,565 9.40% ✗ $5M
May 22, 2023 May 24, 2023 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Apr 4, 2023 Apr 6, 2023 Huang Jane President Sell 22.5 -13,280 -35.41% ✗ $81.3K
Mar 1, 2023 Mar 2, 2023 Lim Bryant David Chief Legal Officer, Corp Sec. Neutral 52.5 - 0.00% ✗ -
Feb 22, 2023 Lim Bryant David Chief Legal Counsel, Corp Sec. Neutral 52.5 - 0.00% ✗ -
Feb 7, 2023 Feb 9, 2023 Scherle Peggy Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Feb 7, 2023 Feb 9, 2023 Combs Andrew EVP, Head of Chemistry Neutral 52.5 - 0.00% ✗ -
Feb 7, 2023 Feb 9, 2023 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -
Feb 7, 2023 Feb 9, 2023 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Feb 7, 2023 Feb 9, 2023 Vaddi Krishna CEO Neutral 52.5 - 0.00% ✗ -
Dec 21, 2022 Dec 22, 2022 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -
Dec 20, 2022 Dec 21, 2022 Vaddi Krishna CEO Buy 72.5 +19,188 0.72% ✗ $98.4K
Dec 8, 2022 Dec 12, 2022 Chardonnet Laurent CFO Buy 91.3 +10,000 38.65% ✗ $47.6K
Jun 17, 2022 Jun 22, 2022 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Jun 17, 2022 Jun 22, 2022 FRIEDMAN PAUL A Director Neutral 52.5 - 0.00% ✗ -
Jun 17, 2022 Jun 22, 2022 Dier Mardi Director Neutral 52.5 - 0.00% ✗ -
Jun 17, 2022 Jun 22, 2022 Babler Martin Director Neutral 52.5 - 0.00% ✗ -
Jun 17, 2022 Jun 22, 2022 Bonita David P Director Neutral 52.5 - 0.00% ✗ -
Jun 17, 2022 Jun 22, 2022 BAKER BROS. ADVISORS LP Director Neutral 52.5 - 0.00% ✗ -
Jun 1, 2022 Jun 1, 2022 Chardonnet Laurent CFO Buy 91.3 +10,000 68.97% ✗ $42.3K
May 2, 2022 May 4, 2022 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Apr 6, 2022 Huang Jane President Neutral 52.5 - 0.00% ✗ -
Mar 31, 2022 Apr 4, 2022 Combs Andrew EVP, Head of Chemistry Neutral 52.5 - 0.00% ✗ -
Mar 21, 2022 Mar 22, 2022 Chardonnet Laurent CFO Neutral 90.0 +6,500 81.25% ✗ -
Feb 15, 2022 Feb 17, 2022 Scherle Peggy Chief Scientific Officer Neutral 52.5 - 0.00% ✗ -
Feb 15, 2022 Feb 17, 2022 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -
Feb 15, 2022 Feb 17, 2022 Vaddi Krishna CEO Neutral 52.5 - 0.00% ✗ -
Feb 15, 2022 Feb 17, 2022 Morosini Deborah EVP, Chief of Clinical Affairs Neutral 52.5 - 0.00% ✗ -
Feb 15, 2022 Feb 17, 2022 Combs Andrew EVP, Head of Chemistry Neutral 52.5 - 0.00% ✗ -
Jan 3, 2022 Jan 5, 2022 Sandor Victor Director Neutral 52.5 - 0.00% ✗ -
Dec 15, 2021 Dec 17, 2021 Morosini Deborah EVP, Chief of Clinical Affairs Sell 7.5 -28,751 -98.48% ✓ $373.8K
Dec 13, 2021 Dec 15, 2021 Combs Andrew EVP, Head of Chemistry Buy 87.5 +8,000 3.07% ✗ $94.9K
Dec 13, 2021 Dec 14, 2021 Chardonnet Laurent CFO Neutral 90.0 +5,000 166.67% ✗ -
Dec 13, 2021 Dec 14, 2021 Vaddi Krishna CEO Neutral 60.0 +8,000 0.31% ✗ -
Nov 29, 2021 Dec 1, 2021 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -
Dec 1, 2021 Chardonnet Laurent CFO Neutral 52.5 - 0.00% ✗ -