2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Royston Ivor | Director | 625,545 | Mar 22, 2017 |
| Domain Partners VI, L.P. | — | 444,460 | Mar 8, 2016 |
| Domain Partners VIII, L.P. | — | 360,640 | Mar 8, 2016 |
| Foley Todd | — | 312,085 | Mar 9, 2016 |
| Gadicke Ansbert | — | 312,085 | Mar 9, 2016 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Feb 9, 2026 | Feb 10, 2026 | Metzger Michael A | CEO | Sell | 40.0 | -17,159 | -3.37% | ✗ | $360.8K |
| Feb 9, 2026 | Feb 10, 2026 | Goldan Keith A. | CFO | Sell | 42.5 | -3,410 | -2.37% | ✗ | $71.7K |
| Feb 4, 2026 | Feb 6, 2026 | Metzger Michael A | CEO | Sell | 95.0 | +210,188 | 70.38% | ✗ | $152.8K |
| Jan 30, 2026 | Feb 6, 2026 | Goldan Keith A. | CFO | Sell | 91.3 | +51,387 | 55.58% | ✗ | $32.6K |
| Feb 4, 2026 | Feb 6, 2026 | Jarrett Jennifer | Director | Neutral | 90.0 | +24,000 | 26.67% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Huber Martin H. Jr. | Director | Neutral | 90.0 | +24,000 | 30.38% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Botwood Nicholas A.J. | Head of R&D, CMO | Neutral | 90.0 | +60,000 | 170.62% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Podlesak Dennis | Director | Neutral | 90.0 | +48,000 | 25.03% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Rizo Aleksandra | Director | Neutral | 90.0 | +24,000 | 96.00% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Katkin Keith | Director | Neutral | 90.0 | +24,000 | 24.00% | ✗ | - |
| Feb 4, 2026 | Feb 6, 2026 | Legault Pierre | Director | Neutral | 90.0 | +24,000 | 26.67% | ✗ | - |
| Dec 1, 2025 | Dec 1, 2025 | Goldan Keith A. | CFO | Neutral | 27.5 | -1,224 | -1.31% | ✗ | - |
| Sep 8, 2025 | Sep 8, 2025 | Metzger Michael A | CEO | Sell | 5.0 | -157,307 | -34.50% | ✓ | $2.6M |
| Aug 14, 2025 | Aug 18, 2025 | Podlesak Dennis | Director | Sell | 26.3 | -57,600 | -9.10% | ✓ | $875.1K |
| Jul 31, 2025 | Aug 7, 2025 | Goldan Keith A. | CFO | Buy | 78.8 | +1,226 | 1.33% | ✗ | $10.3K |
| Jul 16, 2025 | Jul 18, 2025 | Goldan Keith A. | CFO | Sell | 46.3 | -1,296 | -1.38% | ✗ | $12K |
| Jul 16, 2025 | Jul 18, 2025 | Metzger Michael A | CEO | Sell | 42.5 | -7,534 | -2.46% | ✗ | $70K |
| May 19, 2025 | May 19, 2025 | Goldan Keith A. | CFO | Neutral | 82.5 | +3,000 | 3.31% | ✗ | - |
| May 16, 2025 | May 19, 2025 | Botwood Nicholas A.J. | Head of R&D, CMO | Buy | 95.0 | +11,765 | 50.28% | ✗ | $105.8K |
| May 19, 2025 | May 19, 2025 | Huber Martin H. Jr. | Director | Buy | 86.3 | +5,000 | 6.76% | ✗ | $45K |
| May 19, 2025 | May 19, 2025 | Katkin Keith | Director | Buy | 95.0 | +10,000 | 11.11% | ✗ | $91.1K |
| May 16, 2025 | Botwood Nicholas A.J. | Head of R&D, CMO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 14, 2025 | Mar 17, 2025 | Metzger Michael A | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2025 | Mar 6, 2025 | Metzger Michael A | CEO | Sell | 41.3 | -7,814 | -2.54% | ✓ | $117.6K |
| Feb 10, 2025 | Feb 12, 2025 | Goldan Keith A. | CFO | Sell | 42.5 | -3,777 | -4.00% | ✗ | $58.6K |
| Feb 10, 2025 | Feb 12, 2025 | Metzger Michael A | CEO | Sell | 42.5 | -13,288 | -4.24% | ✗ | $206K |
| Feb 10, 2025 | Feb 12, 2025 | Gallagher Neil | President | Sell | 42.5 | -4,618 | -5.15% | ✗ | $71.6K |
| Feb 5, 2025 | Feb 7, 2025 | Gallagher Neil | President | Neutral | 90.0 | +41,900 | 87.63% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Goldan Keith A. | CFO | Neutral | 90.0 | +41,900 | 79.62% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Metzger Michael A | CEO | Neutral | 90.0 | +149,500 | 91.21% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Podlesak Dennis | Director | Neutral | 90.0 | +50,000 | 35.27% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Rizo Aleksandra | Director | Neutral | 90.0 | +25,000 | 100.00% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Meury William | Director | Neutral | 90.0 | +25,000 | 38.46% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Katkin Keith | Director | Neutral | 90.0 | +25,000 | 38.46% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Jarrett Jennifer | Director | Neutral | 90.0 | +25,000 | 38.46% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Huber Martin H. Jr. | Director | Neutral | 90.0 | +25,000 | 51.02% | ✗ | - |
| Feb 5, 2025 | Feb 7, 2025 | Legault Pierre | Director | Neutral | 90.0 | +25,000 | 38.46% | ✗ | - |
| Jun 14, 2024 | Jun 17, 2024 | Goldan Keith A. | CFO | Buy | 78.8 | +1,250 | 2.43% | ✗ | $25K |
| May 15, 2024 | May 16, 2024 | Rizo Aleksandra | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 16, 2024 | Rizo Aleksandra | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 7, 2024 | Feb 9, 2024 | Metzger Michael A | CEO | Neutral | 90.0 | +146,250 | 828.19% | ✗ | - |
| Jul 31, 2023 | Feb 9, 2024 | Goldan Keith A. | CFO | Buy | 91.3 | +48,745 | 1854.83% | ✗ | $36.2K |
| Feb 7, 2024 | Feb 9, 2024 | Gallagher Neil | President | Neutral | 90.0 | +47,813 | 100.00% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Huber Martin H. Jr. | Director | Neutral | 90.0 | +17,000 | 53.13% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Jarrett Jennifer | Director | Neutral | 90.0 | +17,000 | 35.42% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Katkin Keith | Director | Neutral | 90.0 | +17,000 | 35.42% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Meury William | Director | Neutral | 90.0 | +17,000 | 35.42% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Morrison Briggs | Director | Neutral | 90.0 | +17,000 | 95.31% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Podlesak Dennis | Director | Neutral | 90.0 | +34,000 | 31.55% | ✗ | - |
| Feb 7, 2024 | Feb 9, 2024 | Legault Pierre | Director | Neutral | 90.0 | +17,000 | 35.42% | ✗ | - |
| Aug 9, 2023 | Aug 10, 2023 | Morrison Briggs | Director | Sell | 20.0 | -52,855 | -74.77% | ✗ | $965.4K |
| Aug 2, 2023 | Aug 3, 2023 | Meury William | Director | Sell | 17.5 | -83,000 | -36.56% | ✗ | $1.7M |
| Jul 10, 2023 | Jul 11, 2023 | Morrison Briggs | Director | Sell | 17.5 | -52,855 | -74.77% | ✗ | $1.1M |
| Jun 13, 2023 | Jun 14, 2023 | Goldan Keith A. | CFO | Sell | 46.3 | -577 | -18.00% | ✗ | $12.9K |
| Jun 9, 2023 | Jun 9, 2023 | Morrison Briggs | Director | Sell | 17.5 | -52,855 | -74.77% | ✗ | $1.1M |
| May 9, 2023 | May 10, 2023 | Morrison Briggs | Director | Sell | 17.5 | -52,855 | -74.77% | ✗ | $1.1M |
| Apr 10, 2023 | Apr 12, 2023 | Morrison Briggs | Director | Sell | 17.5 | -52,855 | -74.77% | ✗ | $1M |
| Apr 10, 2023 | Apr 12, 2023 | Gallagher Neil | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 12, 2023 | Gallagher Neil | President | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 13, 2023 | Mar 14, 2023 | Morrison Briggs | President | Sell | 5.0 | -52,854 | -74.77% | ✓ | $1.2M |
| Feb 15, 2023 | Feb 17, 2023 | Ordentlich Peter | Chief Scientific Officer | Sell | 7.5 | -25,000 | -100.00% | ✓ | $646.1K |
| Feb 6, 2023 | Feb 8, 2023 | Metzger Michael A | CEO | Sell | 10.0 | -5,959 | -25.23% | ✓ | $164.7K |
| Feb 6, 2023 | Feb 8, 2023 | Morrison Briggs | President | Sell | 5.0 | -52,854 | -74.77% | ✓ | $1.4M |
| Feb 2, 2023 | Feb 3, 2023 | Metzger Michael A | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Morrison Briggs | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Madigan Catherine | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Goldan Keith A. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 31, 2023 | Feb 3, 2023 | Ordentlich Peter | Chief Scientific Officer | Sell | 52.5 | - | 0.00% | ✗ | $766.5 |
| Feb 2, 2023 | Feb 3, 2023 | Nolte Alexander | Chief Accounting Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Podlesak Dennis | Director | Neutral | 90.0 | +32,000 | 42.24% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Huber Martin H. Jr. | Director | Neutral | 90.0 | +16,000 | 100.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Meury William | Director | Neutral | 90.0 | +16,000 | 50.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Legault Pierre | Director | Neutral | 90.0 | +16,000 | 50.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Katkin Keith | Director | Neutral | 90.0 | +16,000 | 50.00% | ✗ | - |
| Feb 2, 2023 | Feb 3, 2023 | Jarrett Jennifer | Director | Neutral | 90.0 | +16,000 | 50.00% | ✗ | - |
| Jan 12, 2023 | Jan 13, 2023 | Legault Pierre | Director | Sell | 5.0 | -39,000 | -28.89% | ✓ | $1M |
| Dec 5, 2022 | Dec 5, 2022 | Sabus Steve M | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 5, 2022 | Sabus Steve M | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 1, 2022 | Dec 2, 2022 | Ordentlich Peter | Chief Scientific Officer | Sell | 7.5 | -25,000 | -96.92% | ✓ | $626K |
| Oct 6, 2022 | Oct 7, 2022 | Katkin Keith | Director | Sell | 7.5 | -29,899 | -31.84% | ✓ | $774.4K |
| Oct 6, 2022 | Oct 7, 2022 | Metzger Michael A | CEO | Sell | 7.5 | -16,231 | -47.89% | ✓ | $410.5K |
| Sep 30, 2022 | Oct 4, 2022 | Metzger Michael A | CEO | Sell | 7.5 | -33,769 | -38.93% | ✓ | $844.9K |
| Sep 30, 2022 | Oct 4, 2022 | Katkin Keith | Director | Sell | 41.3 | -4,101 | -2.09% | ✓ | $102.8K |
| Sep 19, 2022 | Sep 21, 2022 | Morrison Briggs | President | Sell | 5.0 | -173,988 | -82.99% | ✓ | $4M |
| Sep 14, 2022 | Sep 16, 2022 | Morrison Briggs | President | Sell | 3.8 | -279,420 | -79.66% | ✓ | $6.6M |
| Sep 15, 2022 | Sep 16, 2022 | Podlesak Dennis | Director | Sell | 5.0 | -78,815 | -25.75% | ✓ | $1.9M |
| Jul 29, 2022 | Aug 26, 2022 | Ordentlich Peter | Chief Scientific Officer | Sell | 7.5 | -24,735 | -96.89% | ✓ | $622.2K |
| Aug 5, 2022 | Aug 9, 2022 | Legault Pierre | Director | Sell | 7.5 | -24,000 | -27.27% | ✓ | $552.4K |
| Jul 25, 2022 | Jul 27, 2022 | Metzger Michael A | CEO | Sell | 7.5 | -31,602 | -47.22% | ✓ | $665.4K |
| Jul 6, 2022 | Jul 8, 2022 | Metzger Michael A | CEO | Sell | 7.5 | -15,109 | -29.96% | ✓ | $318.4K |
| Jul 1, 2022 | Jul 5, 2022 | Morrison Briggs | President | Sell | 5.0 | -62,292 | -77.74% | ✓ | $1.2M |
| Jun 13, 2022 | Jun 15, 2022 | Goldan Keith A. | CFO | Neutral | 90.0 | +3,205 | 100.00% | ✗ | - |
| Jun 15, 2022 | Goldan Keith A. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 1, 2022 | Apr 13, 2022 | Morrison Briggs | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2022 | Apr 5, 2022 | Morrison Briggs | President | Sell | 5.0 | -104,173 | -52.08% | ✓ | $1.8M |
| Mar 1, 2022 | Mar 3, 2022 | Madigan Catherine | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 3, 2022 | Madigan Catherine | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Feb 2, 2022 | Feb 3, 2022 | Metzger Michael A | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 2, 2022 | Feb 3, 2022 | Morrison Briggs | President | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 31, 2022 | Feb 3, 2022 | Ordentlich Peter | Chief Scientific Officer | Sell | 52.5 | - | 0.00% | ✗ | $6K |