Spero Therapeutics, Inc. (SPRO)

Latest Insider Confidence Score

2026Q1

53.2
Bullish

Company insider confidence (by quarter)

2017Q4 2026Q1

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Aquilo Capital Management, LLC 10% Owner 3,419,435 Sep 26, 2022
Aquilo Capital, L.P. 10% Owner 3,419,435 Sep 26, 2022
GSK plc 10% Owner 1,934,006 Jul 17, 2018
Shukla Sath CEO 1,736,883 Feb 5, 2025
Alphabet Inc. — 1,112,473 Nov 1, 2017

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Feb 6, 2026 Feb 9, 2026 Rajavelu Esther Officer Sell 42.5 -87,917 -7.99% ✗ $207.5K
Feb 6, 2026 Feb 9, 2026 Keutzer Timothy COO Sell 46.3 -18,652 -2.45% ✗ $44K
Feb 2, 2026 Feb 5, 2026 Keutzer Timothy COO Sell 87.5 +21,414 2.89% ✗ $101.2K
Feb 2, 2026 Feb 4, 2026 Rajavelu Esther Officer Sell 91.3 +230,558 26.52% ✗ $40.6K
Nov 7, 2025 Nov 12, 2025 Rajavelu Esther Officer Sell 42.5 -40,270 -4.43% ✗ $95.4K
Aug 28, 2025 Sep 3, 2025 Mahadevia Ankit Director Sell 48.8 -6,572 -0.93% ✗ $12.9K
Aug 28, 2025 Sep 3, 2025 Keutzer Timothy COO Sell 52.5 -1,695 -0.23% ✗ $3.3K
Jun 12, 2025 Jun 16, 2025 Mahadevia Ankit Director Neutral 82.5 +20,000 2.90% ✗ -
Jun 12, 2025 Jun 16, 2025 Deshpande Milind Director Neutral 90.0 +20,000 27.99% ✗ -
Jun 12, 2025 Jun 16, 2025 Jackson Scott Thomas Director Neutral 90.0 +20,000 36.36% ✗ -
Jun 12, 2025 Jun 16, 2025 VINK PATRICK V.J.J. Director Neutral 90.0 +20,000 36.36% ✗ -
Jun 12, 2025 Jun 16, 2025 Pottage John C Jr Director Neutral 90.0 +20,000 36.36% ✗ -
Jun 12, 2025 Jun 16, 2025 Smith Cynthia Director Neutral 90.0 +20,000 36.36% ✗ -
Jun 12, 2025 Jun 16, 2025 THOMAS FRANK E Director Neutral 90.0 +20,000 36.36% ✗ -
Jun 12, 2025 Jun 16, 2025 Tregoning Kathleen Director Neutral 90.0 +20,000 36.36% ✗ -
May 2, 2025 May 6, 2025 Rajavelu Esther Officer Neutral 90.0 +185,000 25.53% ✗ -
Feb 3, 2025 Feb 5, 2025 Keutzer Timothy COO Sell 91.3 +209,602 39.41% ✗ $44.1K
Feb 3, 2025 Feb 5, 2025 Rajavelu Esther CFO Sell 91.3 +345,450 91.08% ✗ $16.1K
Feb 3, 2025 Feb 5, 2025 Shukla Sath CEO Sell 95.0 +596,074 52.25% ✗ $121.2K
Feb 5, 2025 Feb 5, 2025 Mahadevia Ankit Director Sell 42.5 -69,219 -9.12% ✗ $54K
Nov 7, 2024 Nov 12, 2024 Rajavelu Esther CFO Sell 42.5 -40,596 -9.67% ✗ $53K
Aug 27, 2024 Aug 29, 2024 Mahadevia Ankit Director Sell 50.0 -5,912 -0.77% ✗ $8K
Aug 27, 2024 Aug 29, 2024 Keutzer Timothy COO Sell 52.5 -2,213 -0.41% ✗ $3K
Aug 27, 2024 Aug 29, 2024 Shukla Sath CEO Sell 52.5 -2,757 -0.24% ✗ $3.7K
Aug 2, 2024 Aug 6, 2024 Shukla Sath CEO Sell 46.3 -32,441 -2.76% ✗ $42.6K
May 29, 2024 May 30, 2024 Deshpande Milind Director Neutral 90.0 +20,000 38.87% ✗ -
May 29, 2024 May 30, 2024 Jackson Scott Thomas Director Neutral 90.0 +20,000 57.14% ✗ -
May 29, 2024 May 30, 2024 VINK PATRICK V.J.J. Director Neutral 90.0 +20,000 57.14% ✗ -
May 29, 2024 May 30, 2024 Mahadevia Ankit Director Neutral 82.5 +20,000 2.68% ✗ -
May 29, 2024 May 30, 2024 Tregoning Kathleen Director Neutral 90.0 +20,000 57.14% ✗ -
May 29, 2024 May 30, 2024 Smith Cynthia Director Neutral 90.0 +20,000 57.14% ✗ -
May 29, 2024 May 30, 2024 THOMAS FRANK E Director Neutral 90.0 +20,000 57.14% ✗ -
May 29, 2024 May 30, 2024 Pottage John C Jr Director Neutral 90.0 +20,000 57.14% ✗ -
Feb 1, 2024 Feb 5, 2024 Keutzer Timothy COO Sell 91.3 +208,760 64.18% ✗ $42.1K
Feb 2, 2024 Feb 5, 2024 Mahadevia Ankit Director Sell 42.5 -63,795 -7.89% ✗ $87.4K
Feb 1, 2024 Feb 5, 2024 JOSEPH TAMARA L Chief Legal Officer Sell 91.3 +208,825 64.69% ✗ $42.3K
Feb 1, 2024 Feb 5, 2024 HAMED KAMAL Chief Medical Officer Sell 91.3 +211,656 36.72% ✗ $38.5K
Feb 1, 2024 Feb 5, 2024 Rajavelu Esther Officer Neutral 90.0 +119,866 39.96% ✗ -
Feb 1, 2024 Feb 5, 2024 Shukla Sath CEO Sell 95.0 +603,507 105.42% ✓ $107.7K
Jan 2, 2024 Jan 4, 2024 Tregoning Kathleen Director Neutral 52.5 - 0.00% ✗ -
Nov 13, 2023 Nov 15, 2023 Rajavelu Esther Officer Neutral 90.0 +300,000 100.00% ✗ -
Nov 15, 2023 Rajavelu Esther Officer Neutral 52.5 - 0.00% ✗ -
Oct 5, 2023 Oct 10, 2023 Pottage John C Jr Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 Smith Cynthia Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 THOMAS FRANK E Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 Deshpande Milind Director Neutral 90.0 +20,000 63.58% ✗ -
Oct 5, 2023 Oct 10, 2023 Tregoning Kathleen Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 VINK PATRICK V.J.J. Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 Jackson Scott Thomas Director Neutral 90.0 +20,000 133.33% ✗ -
Oct 5, 2023 Oct 10, 2023 Mahadevia Ankit Director Neutral 82.5 +20,000 2.54% ✗ -
Sep 13, 2023 Sep 15, 2023 HAMED KAMAL Chief Medical Officer Sell 42.5 -39,496 -6.41% ✗ $50.2K
Aug 28, 2023 Aug 30, 2023 Keutzer Timothy Chief Development Officer Sell 50.0 -1,854 -0.57% ✗ $2.3K
Aug 28, 2023 Aug 30, 2023 JOSEPH TAMARA L Chief Legal Officer Sell 50.0 -1,854 -0.57% ✗ $2.3K
Aug 28, 2023 Aug 30, 2023 Mahadevia Ankit Director Sell 46.3 -9,040 -1.13% ✗ $11.4K
Aug 28, 2023 Aug 30, 2023 Shukla Sath CEO Sell 50.0 -6,017 -1.04% ✓ $7.7K
Aug 1, 2023 Aug 3, 2023 Shukla Sath CEO Neutral 90.0 +266,000 85.12% ✗ -
Jul 24, 2023 DiPalma Stephen J. Officer Neutral 52.5 - 0.00% ✗ -
Jun 12, 2023 Jun 14, 2023 HAMED KAMAL Chief Medical Officer Neutral 90.0 +140,000 29.41% ✗ -
Feb 3, 2023 Feb 6, 2023 Mahadevia Ankit CEO Sell 46.3 -12,286 -1.52% ✗ $22.2K
Feb 1, 2023 Feb 3, 2023 Keutzer Timothy COO Sell 90.0 +262,563 406.56% ✗ $6.3K
Feb 1, 2023 Feb 3, 2023 JOSEPH TAMARA L Chief Legal Officer Sell 90.0 +262,563 422.94% ✗ $6.3K
Feb 1, 2023 Feb 3, 2023 Shukla Sath CFO Sell 91.3 +256,453 457.43% ✓ $17.4K
Feb 1, 2023 Feb 3, 2023 HAMED KAMAL Chief Medical Officer Neutral 90.0 +265,957 126.65% ✗ -
Feb 1, 2023 Feb 3, 2023 Mahadevia Ankit CEO Neutral 90.0 +531,914 191.20% ✗ -
Jan 3, 2023 Jan 5, 2023 Tregoning Kathleen Director Neutral 52.5 - 0.00% ✗ -
Jan 3, 2023 Jan 5, 2023 VINK PATRICK V.J.J. Director Neutral 52.5 - 0.00% ✗ -
Sep 22, 2022 Sep 26, 2022 Aquilo Capital Management, LLC 10% Owner Sell 17.5 -1,901,796 -35.74% ✗ $4.3M
Sep 15, 2022 Sep 19, 2022 Jackson Scott Thomas Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 15, 2022 Sep 19, 2022 Deshpande Milind Director Neutral 90.0 +15,000 91.16% ✗ -
Sep 15, 2022 Sep 19, 2022 Pottage John C Jr Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 15, 2022 Sep 19, 2022 Smith Cynthia Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 15, 2022 Sep 19, 2022 THOMAS FRANK E Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 15, 2022 Sep 19, 2022 Tregoning Kathleen Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 15, 2022 Sep 19, 2022 VINK PATRICK V.J.J. Director Neutral 90.0 +15,000 100.00% ✗ -
Sep 12, 2022 Sep 14, 2022 HAMED KAMAL Chief Medical Officer Neutral 90.0 +210,000 100.00% ✗ -
Sep 14, 2022 HAMED KAMAL Chief Medical Officer Neutral 52.5 - 0.00% ✗ -
Aug 29, 2022 Aug 30, 2022 Shukla Sath CFO Sell 33.8 -6,017 -9.69% ✓ $5.4K
Apr 26, 2022 Apr 28, 2022 Aquilo Capital Management, LLC 10% Owner Buy 72.5 +39,727 0.75% ✗ $208K
Mar 30, 2022 Mar 31, 2022 Aquilo Capital Management, LLC 10% Owner Buy 75.0 +50,000 0.96% ✗ $439.4K
Mar 14, 2022 Mar 16, 2022 Aquilo Capital Management, LLC 10% Owner Buy 65.0 +23,708 0.23% ✗ $180.8K
Feb 28, 2022 Mar 2, 2022 Aquilo Capital Management, LLC 10% Owner Buy 75.0 +44,833 0.87% ✗ $427.2K
Feb 18, 2022 Feb 23, 2022 Aquilo Capital Management, LLC 10% Owner Buy 65.0 +14,828 0.29% ✗ $137K
Feb 1, 2022 Feb 3, 2022 Melnick David A. Chief Medical Officer Neutral 90.0 +38,014 157.95% ✗ -
Feb 1, 2022 Feb 3, 2022 Shukla Sath CFO Neutral 90.0 +38,014 157.95% ✗ -
Feb 1, 2022 Feb 3, 2022 Larkin Cristina COO Neutral 90.0 +38,014 148.68% ✗ -
Feb 1, 2022 Feb 3, 2022 Mahadevia Ankit CEO Neutral 90.0 +134,168 93.15% ✗ -
Feb 1, 2022 Feb 3, 2022 Keutzer Timothy Chief Development Officer Neutral 90.0 +38,014 143.09% ✗ -
Feb 1, 2022 Feb 3, 2022 JOSEPH TAMARA L Chief Legal Officer Neutral 90.0 +38,014 157.95% ✗ -
Jan 31, 2022 Feb 1, 2022 Aquilo Capital Management, LLC 10% Owner Buy 87.5 +125,000 2.49% ✗ $1.4M
Jan 24, 2022 Jan 26, 2022 Aquilo Capital Management, LLC 10% Owner Buy 48.8 +1,599 0.03% ✗ $17.4K
Jan 18, 2022 Jan 20, 2022 Aquilo Capital Management, LLC 10% Owner Buy 75.0 +48,488 0.98% ✗ $602K
Jan 10, 2022 Jan 12, 2022 Aquilo Capital Management, LLC 10% Owner Buy 60.0 +8,867 0.18% ✗ $114.6K
Jan 5, 2022 Jan 7, 2022 Tregoning Kathleen Director Neutral 52.5 - 0.00% ✗ -
Jan 5, 2022 Jan 7, 2022 THOMAS FRANK E Director Neutral 52.5 - 0.00% ✗ -
Jan 5, 2022 Jan 7, 2022 VINK PATRICK V.J.J. Director Neutral 52.5 - 0.00% ✗ -
Dec 29, 2021 Jan 3, 2022 Aquilo Capital Management, LLC 10% Owner Buy 92.5 +250,493 2.64% ✗ $3.9M
Dec 27, 2021 Dec 29, 2021 Mahadevia Ankit CEO Sell 32.5 -8,000 -5.26% ✓ $116.7K
Nov 11, 2021 Nov 12, 2021 Tregoning Kathleen Director Neutral 52.5 - 0.00% ✗ -
Oct 29, 2021 Nov 2, 2021 Aquilo Capital Management, LLC 10% Owner Buy 92.5 +150,000 3.29% ✗ $2.6M
Oct 14, 2021 Tregoning Kathleen Director Neutral 52.5 - 0.00% ✗ -