2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Pratik Shah Living Trust dated June 15, 2011 | — | 7,490,404 | Jun 7, 2024 |
| Flynn James E | 10% Owner | 4,887,254 | Jul 1, 2025 |
| Deerfield Management Company, L.P. (Series C) | 10% Owner | 4,887,254 | Jul 1, 2025 |
| Deerfield Mgmt IV, L.P. | 10% Owner | 4,887,254 | Jul 1, 2025 |
| Deerfield Private Design Fund IV, L.P. | 10% Owner | 4,887,254 | Jul 1, 2025 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Jan 2, 2026 | Jan 5, 2026 | Scott Kathleen D. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Karas Eric | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Fitzpatrick Alexander A | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Dorsey Brian | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Chakma Justin | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2026 | Jan 5, 2026 | Lowenthal Richard E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Nov 13, 2025 | Nov 14, 2025 | Dorsey Brian | COO | Sell | 22.5 | -21,828 | -66.92% | ✗ | $190K |
| Nov 12, 2025 | Nov 14, 2025 | Chakma Justin | Chief Business Officer | Sell | 17.5 | -166,380 | -100.00% | ✗ | $1.5M |
| Nov 12, 2025 | Nov 14, 2025 | Shah Pratik | Director | Neutral | 27.5 | -350,000 | -7.25% | ✗ | - |
| Aug 21, 2025 | Aug 22, 2025 | Lowenthal Richard E | CEO | Sell | 46.3 | -50,000 | -0.44% | ✓ | $724.3K |
| Aug 21, 2025 | Aug 22, 2025 | Scott Kathleen D. | CFO | Sell | 10.0 | -12,500 | -40.59% | ✓ | $187.5K |
| Aug 19, 2025 | Aug 21, 2025 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 46.3 | -50,000 | -0.44% | ✓ | $703.8K |
| Jul 1, 2025 | Jul 3, 2025 | Karas Eric | Chief Commercial Officer | Sell | 7.5 | -15,000 | -59.25% | ✓ | $254.9K |
| Jun 27, 2025 | Jul 1, 2025 | Flynn James E | 10% Owner | Sell | 15.0 | -740,149 | -7.04% | ✗ | $13.7M |
| Jun 25, 2025 | Jun 27, 2025 | RA CAPITAL MANAGEMENT, L.P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Dadoo Rajeev | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Shah Pratik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Kelly Michael | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Islam Saqib | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | SAUNDERS BRENT L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | SCHNEIDER PHILLIP M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 25, 2025 | Jun 27, 2025 | Shawver Laura | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 18, 2025 | Jun 20, 2025 | Karas Eric | Chief Commercial Officer | Sell | 10.0 | -15,000 | -66.09% | ✓ | $240K |
| May 20, 2025 | May 22, 2025 | Fitzpatrick Alexander A | Chief Legal Officer | Sell | 17.5 | -102,969 | -53.47% | ✗ | $1.5M |
| May 20, 2025 | May 22, 2025 | SAUNDERS BRENT L | Director | Sell | 17.5 | -120,000 | -100.00% | ✗ | $1.7M |
| May 20, 2025 | May 22, 2025 | Scott Kathleen D. | CFO | Sell | 20.0 | -50,000 | -76.13% | ✗ | $705.2K |
| Apr 7, 2025 | Apr 8, 2025 | Shawver Laura | Director | Sell | 17.5 | -50,002 | -19.21% | ✓ | $615.1K |
| Mar 20, 2025 | Mar 21, 2025 | Karas Eric | Chief Commercial Officer | Sell | 10.0 | -10,000 | -56.51% | ✓ | $140K |
| Mar 5, 2025 | Mar 7, 2025 | Shawver Laura | Director | Sell | 22.5 | -50,000 | -10.62% | ✓ | $560.4K |
| Feb 3, 2025 | Feb 4, 2025 | Shawver Laura | Director | Sell | 17.5 | -50,000 | -19.21% | ✓ | $615.6K |
| Jan 6, 2025 | Jan 7, 2025 | Shawver Laura | Director | Sell | 17.5 | -50,000 | -19.21% | ✓ | $555.1K |
| Jan 2, 2025 | Jan 3, 2025 | Fitzpatrick Alexander A | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Dorsey Brian | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Lowenthal Richard E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Chakma Justin | Chief Business Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Scott Kathleen D. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 2, 2025 | Jan 3, 2025 | Karas Eric | Chief Commercial Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 17, 2024 | Dec 19, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.87% | ✓ | $1.2M |
| Dec 17, 2024 | Dec 19, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.87% | ✓ | $1.2M |
| Dec 12, 2024 | Dec 13, 2024 | Chakma Justin | Chief Business Officer | Sell | 17.5 | -144,605 | -34.65% | ✗ | $1.8M |
| Dec 11, 2024 | Dec 13, 2024 | Dorsey Brian | COO | Sell | 7.5 | -40,000 | -76.85% | ✓ | $493.9K |
| Dec 10, 2024 | Dec 12, 2024 | Chakma Justin | Chief Business Officer | Sell | 20.0 | -50,000 | -26.83% | ✗ | $657.6K |
| Dec 10, 2024 | Dec 11, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.86% | ✓ | $1.3M |
| Dec 10, 2024 | Dec 11, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.86% | ✓ | $1.3M |
| Dec 6, 2024 | Dec 9, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 6, 2024 | Dec 9, 2024 | Lowenthal Richard E | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 4, 2024 | Dec 6, 2024 | Chakma Justin | Chief Business Officer | Sell | 17.5 | -144,640 | -26.12% | ✗ | $2M |
| Dec 2, 2024 | Dec 4, 2024 | Chakma Justin | Chief Business Officer | Sell | 17.5 | -90,000 | -24.81% | ✗ | $1.2M |
| Dec 2, 2024 | Dec 4, 2024 | Shawver Laura | Director | Sell | 15.0 | -200,000 | -19.19% | ✓ | $2.7M |
| Dec 2, 2024 | Dec 4, 2024 | Karas Eric | Chief Commercial Officer | Sell | 10.0 | -10,000 | -46.76% | ✓ | $140.4K |
| Nov 25, 2024 | Nov 27, 2024 | Chakma Justin | Chief Business Officer | Sell | 17.5 | -100,000 | -42.30% | ✗ | $1.4M |
| Nov 19, 2024 | Nov 21, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.86% | ✓ | $1.4M |
| Nov 19, 2024 | Nov 21, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.86% | ✓ | $1.4M |
| Nov 12, 2024 | Nov 14, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.77% | ✓ | $1.7M |
| Nov 12, 2024 | Nov 14, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.85% | ✓ | $1.7M |
| Nov 11, 2024 | Nov 13, 2024 | Flynn James E | 10% Owner | Sell | 15.0 | -563,270 | -5.08% | ✗ | $10.1M |
| Oct 16, 2024 | Oct 17, 2024 | Scott Kathleen D. | CFO | Sell | 10.0 | -12,500 | -48.64% | ✓ | $200K |
| Oct 15, 2024 | Oct 17, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.84% | ✓ | $1.5M |
| Oct 15, 2024 | Oct 17, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.84% | ✓ | $1.5M |
| Oct 8, 2024 | Oct 10, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.84% | ✓ | $1.4M |
| Oct 8, 2024 | Oct 10, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.84% | ✓ | $1.4M |
| Sep 18, 2024 | Sep 19, 2024 | Karas Eric | Chief Commercial Officer | Sell | 10.0 | -10,000 | -63.72% | ✓ | $140K |
| Sep 17, 2024 | Sep 19, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.83% | ✓ | $1.3M |
| Sep 17, 2024 | Sep 19, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.83% | ✓ | $1.3M |
| Sep 10, 2024 | Sep 12, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.82% | ✓ | $1.1M |
| Sep 10, 2024 | Sep 12, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.82% | ✓ | $1.1M |
| Aug 26, 2024 | Aug 28, 2024 | Thompson Peter A. | Director | Sell | 17.5 | -83,695 | -100.00% | ✗ | $1.1M |
| Aug 26, 2024 | Aug 28, 2024 | ORBIMED ADVISORS LLC | Director | Sell | 17.5 | -83,695 | -100.00% | ✗ | $1.1M |
| Aug 21, 2024 | Aug 23, 2024 | Thompson Peter A. | Director | Sell | 15.0 | -868,682 | -91.21% | ✗ | $11.5M |
| Aug 21, 2024 | Aug 23, 2024 | ORBIMED ADVISORS LLC | Director | Sell | 15.0 | -868,682 | -91.21% | ✗ | $11.5M |
| Aug 20, 2024 | Aug 21, 2024 | Dorsey Brian | COO | Sell | 7.5 | -50,000 | -89.25% | ✓ | $750K |
| Aug 19, 2024 | Aug 21, 2024 | Karas Eric | Chief Commercial Officer | Sell | 10.0 | -10,000 | -63.72% | ✓ | $140K |
| Aug 20, 2024 | Aug 21, 2024 | Scott Kathleen D. | CFO | Sell | 10.0 | -12,500 | -48.64% | ✓ | $200K |
| Aug 20, 2024 | Aug 21, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.82% | ✓ | $1.5M |
| Aug 20, 2024 | Aug 21, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.82% | ✓ | $1.5M |
| Aug 13, 2024 | Aug 15, 2024 | Dorsey Brian | COO | Sell | 7.5 | -30,000 | -83.28% | ✓ | $390K |
| Aug 13, 2024 | Aug 15, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.72% | ✓ | $1.2M |
| Aug 13, 2024 | Aug 15, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.81% | ✓ | $1.2M |
| Jul 16, 2024 | Jul 18, 2024 | Lowenthal Richard E | CEO | Sell | 42.5 | -100,000 | -0.80% | ✓ | $1.1M |
| Jul 16, 2024 | Jul 18, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 42.5 | -100,000 | -0.80% | ✓ | $1.1M |
| Jul 9, 2024 | Jul 11, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 45.0 | -100,000 | -0.80% | ✓ | $961.7K |
| Jul 9, 2024 | Jul 11, 2024 | Lowenthal Richard E | CEO | Sell | 45.0 | -100,000 | -0.80% | ✓ | $961.7K |
| Jun 20, 2024 | Jun 24, 2024 | RA CAPITAL MANAGEMENT, L.P. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Dadoo Rajeev | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Shawver Laura | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Shah Pratik | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | SCHNEIDER PHILLIP M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Islam Saqib | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Kelly Michael | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | Thompson Peter A. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 20, 2024 | Jun 24, 2024 | SAUNDERS BRENT L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 13, 2024 | Jun 17, 2024 | Shah Pratik | Director | Neutral | 27.5 | -1,332,900 | -21.65% | ✗ | - |
| Jun 11, 2024 | Jun 13, 2024 | Lowenthal Richard E | CEO | Sell | 45.0 | -100,000 | -0.79% | ✓ | $913.9K |
| Jun 11, 2024 | Jun 13, 2024 | Tanimoto Sarina | CHIEF MEDICAL OFFICER | Sell | 45.0 | -100,000 | -0.79% | ✓ | $913.9K |
| Jun 7, 2024 | Jun 7, 2024 | Shah Pratik | Director | Neutral | 27.5 | -1,332,950 | -17.80% | ✗ | - |
| Jun 4, 2024 | Jun 7, 2024 | Shah Pratik | Director | Neutral | 27.5 | -2,665,800 | -26.25% | ✗ | - |
| Jun 4, 2024 | Jun 6, 2024 | Shah Pratik | Director | Neutral | 27.5 | -2,665,800 | -26.25% | ✗ | - |