VYNE Therapeutics Inc. (VYNE)

Latest Insider Confidence Score

2025Q4

49.6
Bearish

Company insider confidence (by quarter)

2018Q1 2025Q4

Largest shareholders

Insider Role (last 12 mo) Shares held Filed at
Perceptive Advisors Llc 10% Owner 4,935,057 Aug 18, 2021
Perceptive Life Sciences Master Fund Ltd 10% Owner 4,935,057 Aug 18, 2021
Edelman Joseph 10% Owner 4,935,057 Aug 18, 2021
Venbio Global Strategic Fund II L.P. 10% Owner 1,196,552 Jan 29, 2018
AI Biotechnology LLC — 1,116,585 Nov 13, 2023

Recent buy/sell transactions

Exec date Filing date Insider Role Signal Confidence Shares % of shares Under plan? Amount (USD)
Dec 31, 2025 Jan 5, 2026 Domzalski David CEO Sell 47.5 -12,684 -2.96% ✗ $7.4K
Dec 31, 2025 Jan 5, 2026 Zeronda Tyler CFO Sell 47.5 -7,858 -7.04% ✗ $4.6K
Dec 31, 2025 Jan 5, 2026 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 47.5 -2,448 -2.08% ✗ $1.4K
Dec 31, 2025 Jan 5, 2026 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 47.5 -3,579 -2.76% ✗ $2.1K
Dec 12, 2025 Dec 15, 2025 Little Elisabeth Sandoval Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2025 Dec 15, 2025 LEPORE PATRICK G Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2025 Dec 15, 2025 Basta Steven L Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2025 Dec 15, 2025 BARBARI SHARON Director Neutral 52.5 - 0.00% ✗ -
Sep 30, 2025 Oct 2, 2025 Zeronda Tyler CFO Sell 47.5 -3,420 -2.97% ✗ $1.1K
Sep 30, 2025 Oct 2, 2025 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 47.5 -2,453 -2.04% ✗ $821.8
Sep 30, 2025 Oct 2, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 47.5 -3,581 -2.69% ✗ $1.2K
Sep 30, 2025 Oct 2, 2025 Domzalski David CEO Sell 47.5 -12,676 -2.87% ✗ $4.2K
Jun 30, 2025 Jul 2, 2025 Zeronda Tyler CFO Sell 47.5 -3,420 -2.89% ✗ $5.6K
Jun 30, 2025 Jul 2, 2025 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 47.5 -2,453 -2.00% ✗ $4K
Jun 30, 2025 Jul 2, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 47.5 -3,581 -2.62% ✗ $5.9K
Jun 30, 2025 Jul 2, 2025 Domzalski David CEO Sell 46.3 -12,676 -2.79% ✗ $20.9K
Jun 2, 2025 Jun 3, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Neutral 67.5 +1,145 0.85% ✗ -
Jun 2, 2025 Jun 3, 2025 Domzalski David CEO Neutral 77.5 +8,681 1.95% ✗ -
Mar 31, 2025 Apr 2, 2025 Zeronda Tyler CFO Sell 46.3 -8,399 -6.62% ✗ $13.3K
Mar 31, 2025 Apr 2, 2025 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 47.5 -6,044 -4.70% ✗ $9.5K
Mar 31, 2025 Apr 2, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 46.3 -8,828 -6.12% ✗ $13.9K
Mar 31, 2025 Apr 2, 2025 Domzalski David CEO Sell 46.3 -30,498 -6.41% ✗ $48.2K
Jan 21, 2025 Jan 23, 2025 Zeronda Tyler CFO Neutral 52.5 - 0.00% ✗ -
Jan 21, 2025 Jan 23, 2025 Stuart Iain CHIEF SCIENTIFIC OFFICER Neutral 52.5 - 0.00% ✗ -
Jan 21, 2025 Jan 23, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Neutral 52.5 - 0.00% ✗ -
Jan 21, 2025 Jan 23, 2025 Domzalski David CEO Neutral 52.5 - 0.00% ✗ -
Jan 15, 2025 Jan 16, 2025 LEPORE PATRICK G Director Buy 91.3 +15,000 41.13% ✗ $43.8K
Dec 31, 2024 Jan 2, 2025 Zeronda Tyler CFO Sell 46.3 -4,675 -3.55% ✗ $15.7K
Dec 31, 2024 Jan 2, 2025 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 46.3 -4,857 -3.64% ✗ $16.3K
Dec 31, 2024 Jan 2, 2025 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 46.3 -4,697 -3.15% ✗ $15.7K
Dec 31, 2024 Jan 2, 2025 Domzalski David CEO Sell 42.5 -24,536 -4.90% ✗ $82.2K
Dec 12, 2024 Dec 13, 2024 Borowski Christine Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2024 Dec 13, 2024 LEPORE PATRICK G Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2024 Dec 13, 2024 Basta Steven L Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2024 Dec 13, 2024 BARBARI SHARON Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2024 Dec 13, 2024 Sandoval Elisabeth Director Neutral 52.5 - 0.00% ✗ -
Dec 12, 2024 Dec 13, 2024 Bruno Anthony D Director Neutral 52.5 - 0.00% ✗ -
Nov 30, 2024 Dec 3, 2024 Domzalski David CEO Neutral 67.5 +3,901 0.79% ✗ -
Sep 30, 2024 Oct 2, 2024 Zeronda Tyler CFO Sell 52.5 -84 -0.06% ✗ $157.9
Sep 30, 2024 Oct 2, 2024 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 52.5 -109 -0.08% ✗ $204.9
Sep 30, 2024 Oct 2, 2024 Domzalski David CEO Sell 52.5 -685 -0.14% ✗ $1.3K
Sep 30, 2024 Oct 2, 2024 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 52.5 -105 -0.07% ✗ $197.4
Jul 1, 2024 Jul 3, 2024 Zeronda Tyler CFO Sell 52.5 -92 -0.07% ✗ $176.6
Jul 1, 2024 Jul 3, 2024 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 52.5 -138 -0.10% ✗ $265
Jul 1, 2024 Jul 3, 2024 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 52.5 -143 -0.10% ✗ $274.6
Jul 1, 2024 Jul 3, 2024 Domzalski David CEO Sell 52.5 -935 -0.19% ✗ $1.8K
May 31, 2024 Jun 4, 2024 Domzalski David CEO Neutral 67.5 +4,429 0.90% ✗ -
Apr 1, 2024 Apr 3, 2024 Zeronda Tyler CFO Sell 52.5 -94 -0.07% ✗ $289.5
Apr 1, 2024 Apr 3, 2024 Stuart Iain CHIEF SCIENTIFIC OFFICER Sell 52.5 -157 -0.12% ✗ $483.6
Apr 1, 2024 Apr 3, 2024 Harsch Mutya CHIEF LEGAL OFFICER AND GC Sell 52.5 -161 -0.11% ✗ $495.9
Apr 1, 2024 Apr 3, 2024 Domzalski David CEO Sell 52.5 -1,004 -0.20% ✗ $3.1K
Jan 1, 2024 Jan 3, 2024 Zeronda Tyler CFO Sell 90.0 +62,407 89.88% ✗ $212
Jan 1, 2024 Jan 3, 2024 Stuart Iain Chief Scientific Officer Sell 90.0 +62,343 87.13% ✗ $358
Jan 1, 2024 Jan 3, 2024 Harsch Mutya Chief Legal Officer and GC Sell 90.0 +62,339 71.58% ✗ $367.1
Jan 1, 2024 Jan 3, 2024 Domzalski David CEO Sell 90.0 +223,996 82.60% ✗ $2.3K
Jan 1, 2024 Jan 3, 2024 Sandoval Elisabeth Director Neutral 52.5 - 0.00% ✗ -
Jan 1, 2024 Jan 3, 2024 LEPORE PATRICK G Director Neutral 52.5 - 0.00% ✗ -
Jan 1, 2024 Jan 3, 2024 Bruno Anthony D Director Neutral 52.5 - 0.00% ✗ -
Jan 1, 2024 Jan 3, 2024 Basta Steven L Director Neutral 52.5 - 0.00% ✗ -
Jan 1, 2024 Jan 3, 2024 BARBARI SHARON Director Neutral 52.5 - 0.00% ✗ -
Jan 1, 2024 Jan 3, 2024 Borowski Christine Director Neutral 52.5 - 0.00% ✗ -
Jan 3, 2024 Borowski Christine Director Neutral 52.5 - 0.00% ✗ -
Dec 13, 2023 Dec 15, 2023 Zeronda Tyler CFO Neutral 90.0 +62,500 901.88% ✗ -
Dec 13, 2023 Dec 15, 2023 Stuart Iain Chief Scientific Officer Neutral 90.0 +62,500 690.23% ✗ -
Dec 13, 2023 Dec 15, 2023 Harsch Mutya Chief Legal Officer and GC Neutral 90.0 +62,500 254.11% ✗ -
Dec 13, 2023 Dec 15, 2023 Domzalski David CEO Neutral 90.0 +225,000 487.35% ✗ -
Dec 13, 2023 Dec 15, 2023 Sandoval Elisabeth Director Neutral 52.5 - 0.00% ✗ -
Dec 13, 2023 Dec 15, 2023 LEPORE PATRICK G Director Neutral 52.5 - 0.00% ✗ -
Dec 13, 2023 Dec 15, 2023 Bruno Anthony D Director Neutral 52.5 - 0.00% ✗ -
Dec 13, 2023 Dec 15, 2023 Basta Steven L Director Neutral 52.5 - 0.00% ✗ -
Dec 13, 2023 Dec 15, 2023 BARBARI SHARON Director Neutral 52.5 - 0.00% ✗ -
Nov 30, 2023 Dec 4, 2023 Domzalski David CEO Neutral 85.0 +2,284 5.20% ✗ -
Nov 15, 2023 Nov 17, 2023 LEPORE PATRICK G Director Buy 95.0 +13,000 55.39% ✗ $50.8K
Nov 13, 2023 AI Biotechnology LLC 10% Owner Neutral 52.5 - 0.00% ✗ -
Oct 2, 2023 Oct 4, 2023 Zeronda Tyler CFO Sell 47.5 -1,087 -13.56% ✗ $4.2K
Oct 2, 2023 Oct 4, 2023 Stuart Iain Chief Scientific Officer Sell 47.5 -1,184 -11.56% ✗ $4.5K
Oct 2, 2023 Oct 4, 2023 Harsch Mutya Chief Legal Officer and GC Sell 47.5 -1,154 -4.48% ✗ $4.4K
Oct 2, 2023 Oct 4, 2023 Domzalski David CEO Sell 46.3 -8,549 -16.30% ✗ $32.7K
Jun 30, 2023 Jul 5, 2023 Zeronda Tyler CFO Sell 47.5 -91 -1.12% ✗ $373.1
Jun 30, 2023 Jul 5, 2023 Stuart Iain Chief Scientific Officer Sell 47.5 -151 -1.45% ✗ $619.1
Jun 30, 2023 Jul 5, 2023 Harsch Mutya Chief Legal Officer and GC Sell 50.0 -157 -0.61% ✗ $643.7
Jun 30, 2023 Jul 5, 2023 Domzalski David CEO Sell 47.5 -981 -1.84% ✗ $4K
May 31, 2023 Jun 2, 2023 Harsch Mutya Chief Legal Officer and GC Neutral 90.0 +3,664 16.47% ✗ -
May 31, 2023 Jun 2, 2023 Domzalski David CEO Neutral 85.0 +2,766 5.46% ✗ -
Mar 31, 2023 Apr 4, 2023 Zeronda Tyler CFO Sell 47.5 -384 -4.52% ✗ $1.2K
Mar 31, 2023 Apr 4, 2023 Stuart Iain Chief Scientific Officer Sell 47.5 -480 -4.42% ✗ $1.5K
Mar 31, 2023 Apr 4, 2023 Harsch Mutya Chief Legal Officer and GC Sell 47.5 -478 -2.10% ✗ $1.5K
Mar 31, 2023 Apr 4, 2023 Domzalski David CEO Sell 47.5 -2,734 -5.12% ✗ $8.4K
Mar 20, 2023 Mar 22, 2023 LEPORE PATRICK G Director Buy 91.3 +20,000 576.04% ✗ $49.7K
Mar 20, 2023 Mar 22, 2023 Harsch Mutya Chief Legal Officer and GC Buy 91.3 +10,000 78.61% ✗ $25K
Dec 31, 2022 Jan 4, 2023 Harsch Mutya Chief Legal Officer and GC Sell 50.0 -1,813 -0.78% ✗ $272
Dec 31, 2022 Jan 4, 2023 Stuart Iain Chief Scientific Officer Sell 50.0 -1,720 -0.77% ✗ $258
Dec 31, 2022 Jan 4, 2023 Zeronda Tyler CFO Sell 52.5 -354 -0.20% ✗ $53.1
Dec 31, 2022 Jan 4, 2023 Domzalski David CEO Sell 50.0 -10,685 -0.99% ✗ $1.6K
Nov 30, 2022 Dec 2, 2022 Domzalski David CEO Neutral 82.5 +34,705 3.34% ✗ -
Sep 30, 2022 Oct 4, 2022 Zeronda Tyler CFO Sell 52.5 -353 -0.20% ✗ $78.7
Sep 30, 2022 Oct 4, 2022 Stuart Iain Chief Scientific Officer Sell 50.0 -1,719 -0.77% ✗ $383.3
Sep 30, 2022 Oct 4, 2022 Harsch Mutya Chief Legal Officer and GC Sell 50.0 -1,813 -0.78% ✗ $404.3
Sep 30, 2022 Oct 4, 2022 Domzalski David CEO Sell 47.5 -10,683 -1.02% ✗ $2.4K
Aug 10, 2022 Aug 12, 2022 Sandoval Elisabeth Director Neutral 52.5 - 0.00% ✗ -