2025Q4
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Orbimed Advisors Llc | 10% Owner | 5,193,946 | Dec 10, 2020 |
| OrbiMed Capital GP V LLC | 10% Owner | 5,193,946 | Dec 10, 2020 |
| Isaly Samuel D | Director | 4,416,446 | Mar 17, 2017 |
| Kinley Matthew P | — | 2,000,000 | Apr 4, 2008 |
| Pappajohn John | — | 2,000,000 | Apr 4, 2008 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Dec 1, 2025 | Dec 2, 2025 | Dugan Margaret | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 2, 2025 | Dugan Margaret | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 17, 2025 | Jun 17, 2025 | Zhao Baiteng | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 17, 2025 | Desai Neil | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Hirmand Mohammad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Maroun Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Castelein Caley | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Dalal Anupam | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2025 | Jun 16, 2025 | Aghazadeh Behzad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2025 | Apr 3, 2025 | BALL BRYAN | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2025 | Apr 3, 2025 | Giacobello Scott M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2025 | Apr 3, 2025 | Lennon David James | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 4, 2025 | Mar 5, 2025 | Dalal Anupam | Director | Neutral | 90.0 | +1,561,000 | 84.35% | ✗ | - |
| Mar 4, 2025 | Mar 4, 2025 | Castelein Caley | Director | Neutral | 90.0 | +1,666,000 | 320.57% | ✗ | - |
| Mar 4, 2025 | Mar 4, 2025 | Zhao Baiteng | Director | Neutral | 90.0 | +1,250,000 | 100.00% | ✗ | - |
| Mar 4, 2025 | Mar 4, 2025 | Dornan David | Chief Scientific Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2025 | Mar 4, 2025 | BALL BRYAN | Officer | Sell | 90.0 | +97,853 | 93.19% | ✗ | $5K |
| Feb 28, 2025 | Mar 4, 2025 | Aghazadeh Behzad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2025 | Mar 3, 2025 | Giacobello Scott M. | CFO | Sell | 47.5 | -2,806 | -10.49% | ✗ | $6.6K |
| Mar 1, 2025 | Mar 3, 2025 | Lennon David James | CEO | Sell | 46.3 | -5,690 | -14.55% | ✗ | $13.4K |
| Feb 18, 2025 | Dornan David | Chief Scientific Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 19, 2024 | Dec 23, 2024 | Zhao Baiteng | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 23, 2024 | Zhao Baiteng | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 2, 2024 | Oct 3, 2024 | Lennon David James | CEO | Sell | 46.3 | -9,689 | -29.76% | ✗ | $18.8K |
| Sep 3, 2024 | Sep 5, 2024 | Desai Neil | Chair | Sell | 41.3 | -40,000 | -2.16% | ✓ | $68.3K |
| Aug 1, 2024 | Aug 5, 2024 | Desai Neil | Chair | Sell | 41.3 | -40,000 | -2.12% | ✓ | $57.4K |
| Jul 1, 2024 | Jul 2, 2024 | Desai Neil | Chair | Sell | 41.3 | -40,000 | -2.07% | ✓ | $57.2K |
| Jun 12, 2024 | Jun 14, 2024 | Aghazadeh Behzad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Maroun Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Hirmand Mohammad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Castelein Caley | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Dalal Anupam | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 12, 2024 | Jun 14, 2024 | Hehenberger Karin M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 3, 2024 | Jun 5, 2024 | Desai Neil | Chair | Sell | 41.3 | -40,000 | -2.03% | ✓ | $71.5K |
| May 1, 2024 | May 1, 2024 | Desai Neil | Chair | Sell | 45.0 | -40,000 | -1.99% | ✓ | $77.2K |
| Apr 26, 2024 | BALL BRYAN | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Apr 1, 2024 | Apr 3, 2024 | Desai Neil | Chair | Sell | 45.0 | -40,000 | -1.95% | ✓ | $90.6K |
| Mar 1, 2024 | Mar 4, 2024 | Desai Neil | Chair | Sell | 45.0 | -42,000 | -1.46% | ✓ | $84.6K |
| Mar 1, 2024 | Mar 4, 2024 | ITRI LORETTTA M | CHIEF MEDICAL OFFICER | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2024 | Mar 4, 2024 | Lennon David James | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2024 | Mar 4, 2024 | Giacobello Scott M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 1, 2024 | Feb 2, 2024 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.81% | ✓ | $73.3K |
| Jan 2, 2024 | Jan 2, 2024 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.73% | ✓ | $86.5K |
| Dec 6, 2023 | Dec 7, 2023 | Desai Neil | Chair | Sell | 52.5 | -7,037 | -0.46% | ✓ | $33.9K |
| Dec 1, 2023 | Dec 5, 2023 | Desai Neil | Chair | Sell | 41.3 | -34,963 | -2.21% | ✓ | $177.8K |
| Nov 1, 2023 | Nov 2, 2023 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.59% | ✓ | $185.7K |
| Oct 2, 2023 | Oct 3, 2023 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.52% | ✓ | $179K |
| Oct 2, 2023 | Oct 3, 2023 | Lennon David James | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 3, 2023 | Lennon David James | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 1, 2023 | Sep 6, 2023 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.46% | ✓ | $238.8K |
| Aug 1, 2023 | Aug 3, 2023 | Desai Neil | Chair | Sell | 41.3 | -42,000 | -2.40% | ✓ | $218.8K |
| Jul 3, 2023 | Jul 6, 2023 | Desai Neil | Chair | Sell | 38.8 | -42,000 | -2.35% | ✓ | $271.6K |
| Jun 15, 2023 | Jun 20, 2023 | Aghazadeh Behzad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Castelein Caley | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Maroun Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Dalal Anupam | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2023 | Jun 20, 2023 | Hehenberger Karin M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 6, 2023 | Jun 6, 2023 | Desai Neil | Chair | Sell | 48.8 | -7,260 | -0.40% | ✓ | $59.5K |
| Jun 1, 2023 | Jun 5, 2023 | Desai Neil | Chair | Sell | 42.5 | -34,740 | -1.90% | ✓ | $279.3K |
| May 4, 2023 | May 5, 2023 | Desai Neil | Chair | Sell | 53.8 | -2,305 | -0.13% | ✓ | $17.4K |
| May 1, 2023 | May 3, 2023 | Desai Neil | Chair | Sell | 38.8 | -39,695 | -2.12% | ✓ | $306.2K |
| Apr 6, 2023 | Apr 6, 2023 | Desai Neil | Chair | Sell | 47.5 | -12,212 | -0.65% | ✓ | $86.6K |
| Apr 3, 2023 | Apr 5, 2023 | Desai Neil | Chair | Sell | 45.0 | -29,788 | -1.56% | ✓ | $218.4K |
| Apr 3, 2023 | Apr 4, 2023 | Giacobello Scott M. | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 27, 2023 | Mar 29, 2023 | Hirmand Mohammad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 29, 2023 | Hirmand Mohammad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Mar 1, 2023 | Mar 2, 2023 | ITRI LORETTTA M | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2023 | Mar 2, 2023 | Giacobello Scott M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 1, 2023 | Mar 2, 2023 | Delaney Brendan | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2023 | Jan 4, 2023 | Delaney Brendan | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2023 | Jan 4, 2023 | Desai Neil | Chair | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 26, 2022 | Sep 27, 2022 | Castelein Caley | Director | Neutral | 90.0 | +240,000 | 85.81% | ✗ | - |
| Sep 26, 2022 | Sep 27, 2022 | Dalal Anupam | Director | Neutral | 90.0 | +320,000 | 20.91% | ✗ | - |
| Sep 26, 2022 | Sep 27, 2022 | Delaney Brendan | COO | Neutral | 90.0 | +20,000 | 100.00% | ✗ | - |
| Sep 26, 2022 | Sep 27, 2022 | Giacobello Scott M. | CFO | Neutral | 90.0 | +20,000 | 100.00% | ✗ | - |
| Sep 22, 2022 | Sep 26, 2022 | Aghazadeh Behzad | Director | Neutral | 90.0 | +1,260,000 | 56.97% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Maroun Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Hehenberger Karin M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Dalal Anupam | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Castelein Caley | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jun 15, 2022 | Jun 17, 2022 | Aghazadeh Behzad | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2022 | Apr 5, 2022 | Delaney Brendan | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2022 | Apr 5, 2022 | ITRI LORETTTA M | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2022 | Apr 5, 2022 | Giacobello Scott M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 1, 2022 | Apr 5, 2022 | Desai Neil | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 18, 2022 | Mar 22, 2022 | Desai Neil | Officer | Sell | 50.0 | -3,550 | -0.18% | ✓ | $71.2K |
| Nov 29, 2021 | Giacobello Scott M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Oct 21, 2021 | Oct 25, 2021 | ITRI LORETTTA M | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 25, 2021 | ITRI LORETTTA M | Chief Medical Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 20, 2021 | Sep 22, 2021 | Delaney Brendan | COO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 22, 2021 | Delaney Brendan | COO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Sep 8, 2021 | Sep 10, 2021 | Desai Neil | Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 8, 2021 | Sep 10, 2021 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 10, 2021 | Reeve Emma | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Aug 27, 2021 | Aug 31, 2021 | Hehenberger Karin M. | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 27, 2021 | Aug 31, 2021 | Maroun Richard E | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |