2026Q1
| Insider | Role (last 12 mo) | Shares held | Filed at |
|---|---|---|---|
| Baker Brothers Life Sciences Capital (GP), LLC | — | 13,606,093 | Mar 8, 2012 |
| Bvf Partners L P/Il | 10% Owner | 5,003,000 | May 20, 2025 |
| Biotechnology Value Fund L P | 10% Owner | 5,003,000 | May 20, 2025 |
| Bvf I Gp Llc | 10% Owner | 5,003,000 | May 20, 2025 |
| Biotechnology Value Fund II Lp | 10% Owner | 5,003,000 | May 20, 2025 |
| Exec date | Filing date | Insider | Role | Signal | Confidence | Shares | % of shares | Under plan? | Amount (USD) |
|---|---|---|---|---|---|---|---|---|---|
| Jan 12, 2026 | Jan 14, 2026 | Trigilio Jeffrey | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 14, 2026 | Trigilio Jeffrey | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Dec 4, 2025 | Dec 8, 2025 | Hughes Owen | CEO | Buy | 100.0 | +100,000 | 99.44% | ✗ | $2.5M |
| Sep 10, 2025 | Sep 12, 2025 | Montano Maricel Perea | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 12, 2025 | Aug 14, 2025 | Montano Maricel Perea | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 14, 2025 | Montano Maricel Perea | Chief Legal Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 30, 2025 | Jul 2, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 90.0 | +2,000 | 8.68% | ✗ | $50.8K |
| May 21, 2025 | May 23, 2025 | Kosacz Barbara | Director | Neutral | 90.0 | +5,971 | 100.00% | ✗ | - |
| May 21, 2025 | May 23, 2025 | WYSZOMIERSKI JACK L | Director | Neutral | 90.0 | +5,971 | 47.64% | ✗ | - |
| May 21, 2025 | May 23, 2025 | LIMBER JOSEPH M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 21, 2025 | May 23, 2025 | PERRY MATTHEW D | Director | Neutral | 90.0 | +5,971 | 33.42% | ✗ | - |
| May 21, 2025 | May 23, 2025 | Hernday Natasha | Director | Neutral | 90.0 | +5,971 | 196.74% | ✗ | - |
| May 21, 2025 | May 23, 2025 | Franklin Heather L | Director | Neutral | 90.0 | +5,971 | 100.00% | ✗ | - |
| May 21, 2025 | May 23, 2025 | Kosacz Barbara | Director | Neutral | 90.0 | +5,971 | 100.00% | ✗ | - |
| May 19, 2025 | May 21, 2025 | Hughes Owen | CEO | Sell | 40.0 | -25,637 | -28.29% | ✗ | $650.7K |
| May 19, 2025 | May 21, 2025 | BURNS THOMAS M. | CFO | Sell | 40.0 | -10,482 | -24.28% | ✗ | $266K |
| May 16, 2025 | May 20, 2025 | BVF PARTNERS L P/IL | 10% Owner | Sell | 15.0 | -392,723 | -13.17% | ✗ | $10.6M |
| Apr 7, 2025 | Apr 9, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +2,000 | 10.31% | ✗ | $49.4K |
| Apr 3, 2025 | Apr 7, 2025 | LIMBER JOSEPH M | Director | Buy | 97.5 | +30,000 | 483.25% | ✗ | $760.1K |
| Mar 31, 2025 | Apr 2, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 86.3 | +1,245 | 6.86% | ✗ | $26.2K |
| Apr 1, 2025 | Apr 2, 2025 | BURNS THOMAS M. | CFO | Buy | 83.8 | +1,000 | 4.10% | ✗ | $25.5K |
| Mar 21, 2025 | Mar 25, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 95.0 | +4,134 | 29.48% | ✗ | $98.8K |
| Jan 24, 2025 | Jan 28, 2025 | BVF PARTNERS L P/IL | 10% Owner | Sell | 15.0 | -650,717 | -17.91% | ✗ | $17M |
| Jan 8, 2025 | Jan 10, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 83.8 | +545 | 4.18% | ✗ | $14K |
| Dec 31, 2024 | Jan 3, 2025 | Sitko Bradley | Chief Investment Officer | Buy | 77.5 | +300 | 2.35% | ✗ | $7.8K |
| Nov 11, 2024 | Nov 13, 2024 | BURNS THOMAS M. | CFO | Sell | 40.0 | -9,775 | -29.73% | ✗ | $292.7K |
| Nov 11, 2024 | Nov 13, 2024 | Hughes Owen | CEO | Sell | 40.0 | -21,881 | -37.17% | ✗ | $655.3K |
| May 15, 2024 | May 17, 2024 | WYSZOMIERSKI JACK L | Director | Neutral | 90.0 | +6,070 | 93.92% | ✗ | - |
| May 15, 2024 | May 17, 2024 | PERRY MATTHEW D | Director | Neutral | 90.0 | +6,070 | 51.45% | ✗ | - |
| May 15, 2024 | May 17, 2024 | LIMBER JOSEPH M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2024 | May 17, 2024 | Kosacz Barbara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 15, 2024 | May 17, 2024 | Hernday Natasha | Director | Neutral | 90.0 | +3,035 | 100.00% | ✗ | - |
| May 15, 2024 | May 17, 2024 | Franklin Heather L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 8, 2024 | Jan 10, 2024 | Hughes Owen | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Oct 2, 2023 | Oct 4, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +1,750 | 23.81% | ✗ | $24.8K |
| Oct 2, 2023 | Oct 4, 2023 | Hughes Owen | CEO | Buy | 91.3 | +1,000 | 22.22% | ✗ | $13.8K |
| Sep 25, 2023 | Sep 27, 2023 | Hughes Owen | CEO | Buy | 91.3 | +2,500 | 125.00% | ✗ | $36.1K |
| May 31, 2023 | Jun 2, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +1,500 | 25.64% | ✗ | $25.7K |
| May 23, 2023 | May 25, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +850 | 17.00% | ✗ | $16.2K |
| May 23, 2023 | May 25, 2023 | Hughes Owen | CEO | Buy | 91.3 | +2,000 | 100.00% | ✗ | $47.3K |
| May 19, 2023 | May 22, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +1,000 | 25.00% | ✗ | $19.5K |
| May 18, 2023 | May 22, 2023 | BURNS THOMAS M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | PERRY MATTHEW D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | WYSZOMIERSKI JACK L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | LIMBER JOSEPH M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | Kosacz Barbara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | Hernday Natasha | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 17, 2023 | May 19, 2023 | Franklin Heather L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 16, 2023 | May 17, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 91.3 | +500 | 14.29% | ✗ | $11.6K |
| May 12, 2023 | May 16, 2023 | Sitko Bradley | Chief Investment Officer | Buy | 95.0 | +3,500 | 100.00% | ✗ | $73.1K |
| Jan 5, 2023 | Jan 9, 2023 | BVF PARTNERS L P/IL | Director | Buy | 67.5 | +22,249 | 0.31% | ✗ | $420.7K |
| Jan 6, 2023 | Hughes Owen | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jan 3, 2023 | Jan 6, 2023 | Sitko Bradley | Chief Investment Officer | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 3, 2023 | Jan 5, 2023 | Hughes Owen | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Jan 5, 2023 | Sitko Bradley | Chief Investment Officer | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Nov 8, 2022 | Nov 9, 2022 | BURNS THOMAS M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Sep 23, 2022 | Sep 27, 2022 | BVF PARTNERS L P/IL | Director | Buy | 67.5 | +24,642 | 0.23% | ✗ | $409.3K |
| Sep 14, 2022 | Sep 16, 2022 | BVF PARTNERS L P/IL | Director | Buy | 75.0 | +56,309 | 0.83% | ✗ | $990.7K |
| Jul 15, 2022 | Jul 18, 2022 | BURNS THOMAS M. | CFO | Sell | 25.0 | -2,000 | -12.58% | ✓ | $63.3K |
| Jul 15, 2022 | Jul 18, 2022 | Neal James R | CEO | Sell | 7.5 | -25,000 | -42.82% | ✓ | $746.1K |
| May 18, 2022 | May 20, 2022 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | LIMBER JOSEPH M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | PERRY MATTHEW D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | WYSZOMIERSKI JACK L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | Hernday Natasha | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | VAN NESS W DENMAN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | Kosacz Barbara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 18, 2022 | May 20, 2022 | Franklin Heather L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Mar 21, 2022 | Mar 23, 2022 | Neal James R | CEO | Sell | 17.5 | -53,450 | -48.38% | ✗ | $1.6M |
| Mar 21, 2022 | Mar 23, 2022 | BURNS THOMAS M. | CFO | Sell | 20.0 | -14,500 | -34.93% | ✗ | $423.1K |
| Feb 22, 2022 | Feb 23, 2022 | BURNS THOMAS M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 21, 2021 | Dec 23, 2021 | Neal James R | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 6, 2021 | Aug 10, 2021 | Franklin Heather L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Aug 10, 2021 | Franklin Heather L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - | |
| Jun 25, 2021 | Jun 29, 2021 | Neal James R | CEO | Sell | 20.0 | -9,027 | -21.59% | ✗ | $303.5K |
| May 19, 2021 | May 21, 2021 | BVF PARTNERS L P/IL | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | PERRY MATTHEW D | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | WYSZOMIERSKI JACK L | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | LIMBER JOSEPH M | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | VAN NESS W DENMAN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | Kosacz Barbara | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| May 19, 2021 | May 21, 2021 | Hernday Natasha | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Apr 9, 2021 | Apr 13, 2021 | Neal James R | CEO | Neutral | 90.0 | +8,000 | 23.66% | ✗ | - |
| Apr 9, 2021 | Apr 13, 2021 | BURNS THOMAS M. | CFO | Neutral | 85.0 | +1,000 | 8.03% | ✗ | - |
| Mar 31, 2021 | Apr 2, 2021 | BVF PARTNERS L P/IL | Director | Sell | 15.0 | -651,700 | -14.87% | ✗ | $25M |
| Mar 15, 2021 | Mar 16, 2021 | VAN NESS W DENMAN | Director | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 17, 2021 | Feb 19, 2021 | Neal James R | CEO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Feb 17, 2021 | Feb 19, 2021 | BURNS THOMAS M. | CFO | Neutral | 52.5 | - | 0.00% | ✗ | - |
| Dec 15, 2020 | Dec 17, 2020 | Neal James R | CEO | Sell | 5.0 | -18,000 | -34.94% | ✓ | $1.1M |
| Dec 15, 2020 | Dec 17, 2020 | BURNS THOMAS M. | CFO | Sell | 7.5 | -13,000 | -51.51% | ✓ | $621.1K |
| Dec 15, 2020 | Dec 17, 2020 | Hernday Natasha | Director | Neutral | 90.0 | +4,000 | 100.00% | ✗ | - |
| Dec 11, 2020 | Dec 15, 2020 | PERRY MATTHEW D | Director | Buy | 100.0 | +200,000 | 1695.06% | ✗ | $5M |
| Dec 11, 2020 | Dec 15, 2020 | BVF PARTNERS L P/IL | Director | Buy | 93.8 | +200,000 | 4.77% | ✗ | $5M |
| Nov 20, 2020 | Nov 24, 2020 | BURNS THOMAS M. | CFO | Sell | 7.5 | -12,000 | -33.54% | ✓ | $392.3K |
| Nov 20, 2020 | Nov 24, 2020 | Neal James R | CEO | Sell | 12.5 | -20,000 | -22.82% | ✓ | $656.2K |
| Nov 5, 2020 | Nov 6, 2020 | Neal James R | CEO | Sell | 7.5 | -10,000 | -28.15% | ✓ | $260.2K |
| Nov 5, 2020 | Nov 6, 2020 | BURNS THOMAS M. | CFO | Sell | 10.0 | -8,000 | -43.86% | ✓ | $208.9K |
| Sep 21, 2020 | Sep 23, 2020 | BVF PARTNERS L P/IL | Director | Buy | 67.5 | +51,368 | 0.45% | ✗ | $942K |
| Sep 4, 2020 | Sep 10, 2020 | BVF PARTNERS L P/IL | Director | Buy | 60.0 | +7,737 | 0.19% | ✗ | $145.2K |